Risk of Vulvar Squamous Cell Carcinoma in Lichen Sclerosus and Lichen Planus: A Systematic Review

Leis, Maria; Singh, Arun; Li, Calandra; Ahluwalia, Renita; Fleming, Patrick; Lynde, Charles

doi:10.1016/j.jogc.2021.09.023

Cited by 27 publications

(18 citation statements)

References 37 publications

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“…In this study, we compared the efficacy of CO 2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions. The results of PGI-C score are consistent with those of Kraus et al as well as Leis et al who reported on 4 cases of vulvar LSC treated with CO 2 lattice laser ( 6 , 7 ). Another comparative study of vulvar epithelial nonneoplastic lesions treated with dot-matrix CO 2 laser was performed.…”

Section: Discussionsupporting

confidence: 90%

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Wei¹,

Li²,

Zhang³

et al. 2023

Ann Transl Med

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Background: A comparison of topical glucocorticoids with CO 2 fractional laser treatment was conducted to investigate the differences in the efficacy of non-neoplastic vulvar epithelial lesion treatments in different pathological types and to provide a scientific basis for the management of these disorders. This paper was to study the difference of curative effect of different pathological types of non-tumor vulvar epithelial lesions and provide scientific basis for the treatment of these diseases. Methods:From November 2016 to July 2018, 178 cases of vulvar lichen simplex chronicus (LSC) or lichen sclerosus were confirmed with vulvar biopsy at our institute. Finally, 160 patients were enrolled in this trial. The patients were divided into 2 groups: a group treated with topical hormone and a group treated with CO 2 lattice laser therapies. There were 80 cases in each group, including 40 with LSC and 40 with lichen sclerosus. Patients applied 1 gram of progesterone cream and betamethasone cream to the affected area in the morning and evening, respectively, once a day for 3 months. The efficacy was evaluated with the Patient Global Impression of Change (PGI-C) subjective symptom improvement scale and clinical efficacy evaluation scale. The formula was applied to calculate the curative effect index. Results:The PGI-C scores at 1, 3, and 6 months of treatment showed that the laser treatment group had remarkably superior outcomes to the glucocorticoid treatment group. The clinical efficacy score scale at 3and 6-month treatments indicated a significantly greater curative effect in the laser than in the glucocorticoid treatment (P=0.006 and P=0.002 respectively). In the glucocorticoid group, the clinical effects of different pathological subtypes were significantly different following the 1-and 3-month treatments. The efficacy of treatment for LSC was better than that for lichen sclerosus. Following the 3-and 6-month treatments, the clinical effect for LSC was better than that of lichen sclerosus (3 months: 95% vs. 75%; 6 months: and 95% vs. 70%).Conclusions: Ultrapulse CO 2 lattice laser was more effective than was glucocorticoid therapy in the treatment of vulvar epithelial non-tumor-like lesions.

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Section: Discussionsupporting

confidence: 90%

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Wei¹,

Li²,

Zhang³

et al. 2023

Ann Transl Med

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“…Lichen sclerosis, lichen planus, and Paget disease of the vulva were associated with vulvar cancer. [35][36][37][38][39][40] These conditions are not thought to involve HPV infection, as is differentiated vulvar intraepithelial neoplasia (VIN), which is associated with incident cancer and progression to vulvar cancer over many years. 41,42 Several studies found that the risk of associated vulvar cancer persisted beyond 5 years after a diagnosis of lichen sclerosis.…”

Section: Other Vulvar Diseasesmentioning

confidence: 99%

Executive Summary of the Lower Anogenital Tract Cancer Evidence Review Conference

Chelmow

Cejtin

Conageski

et al. 2023

Obstetrics &Amp; Gynecology

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The Centers for Disease Control and Prevention sponsored a project conducted by the American College of Obstetricians and Gynecologists to develop educational materials for clinicians on the prevention and early diagnosis of gynecologic cancers. For this final module, focusing on the cancers of the lower anogenital tract (vulva, vagina, and anus), a panel of experts in evidence assessment from the Society for Academic Specialists in General Obstetrics and Gynecology, ASCCP, and the Society of Gynecologic Oncology reviewed relevant literature and current guidelines. Panel members conducted structured literature reviews, which were then reviewed by other panel members. Representatives from stakeholder professional and patient advocacy organizations met virtually in September 2022 to review and provide comment. This article is the executive summary of the review. It covers prevention, early diagnosis, and special considerations of lower anogenital tract cancer. Knowledge gaps are summarized to provide guidance for future research.

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“…10 VLP carries a risk of malignant transformation, with the development of vulvar squamous cell carcinoma (VSCC) in about 1%-33% of LP in association with VSCC but the incidence is unknown. 11 We aimed to use unbiased proteomics methods to detect differentially expressed proteins in tissue of patients with VLP compared to previously published proteomic profiles of (a) normal vulvar tissue (NVT), (b) VLS, and (c) OLP versus normal oral mucosa (NOM) to identify proteins (a) specific to VLP, (b) that differentiate it from VLS and (c) that are common to OLP and VLP.…”

Section: Introductionmentioning

confidence: 99%

Differential proteomic expression profiles in vulvar lichen planus as compared to normal vulvar tissue, vulvar lichen sclerosus, or oral lichen planus: An exploratory study

Xie

Dasari

Deschaine

et al. 2023

Experimental Dermatology

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Vulvar lichen planus (VLP) is a chronic inflammatory disease which adversely affects patients' quality of life. The pathogenesis of VLP is unknown although Th1 immune response has been implicated. We aimed to discover specific tissue‐based protein biomarkers in VLP compared to normal vulvar tissue (NVT), vulvar lichen sclerosus (VLS) and oral lichen planus (OLP). We used laser capture microdissection‐liquid chromatography‐ tandem mass spectrometry to assess protein expression in fixed lesional mucosal specimens from patients with VLP (n = 5). We then compared proteomic profiles against those of NVT (n = 4), VLS (n = 5), OLP (n = 6) and normal oral mucosa (n = 5), previously published by our group. IL16, PTPRC, PTPRCAP, TAP1 and ITGB2 and were significantly overexpressed in VLP compared to NVT. Ingenuity pathway analysis identified antigen presentation and integrin signalling pathways. Proteins overexpressed in both VLP versus NVT and OLP versus NOM included IL16, PTPRC, PTPRCAP, TAP1, HLA‐DPB1, HLA‐B and HLA‐DRA. This proteomic analysis revealed several overexpressed proteins in VLP that relate to Th1 autoimmunity, including IL16. Overlapping pathways, including those involving IFNγ and Th1 signalling, were observed between VLP, VLS, and OLP.

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Risk of Vulvar Squamous Cell Carcinoma in Lichen Sclerosus and Lichen Planus: A Systematic Review

Cited by 27 publications

References 37 publications

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Executive Summary of the Lower Anogenital Tract Cancer Evidence Review Conference

Differential proteomic expression profiles in vulvar lichen planus as compared to normal vulvar tissue, vulvar lichen sclerosus, or oral lichen planus: An exploratory study

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