Risk-scoring system for predicting mucositis in patients of head and neck cancer receiving concurrent chemoradiotherapy [rssm-hn]

Suresh, Amritha; Varma, Parvathi; Sinha, Sudha; Deepika, Satya; Raman, R.; Srinivasan, Muthiah; Mandapal, T; Reddy, C Obula; Anand, Bhavna

doi:10.4103/0973-1482.77100

Cited by 26 publications

(16 citation statements)

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“…Oral mucositis occurs in 15–40% of patients receiving standard chemotherapy, and 100% of patients receiving radiation therapy for head and neck cancer develop oral mucositis of varying degrees [11, 12]. The mechanism by which mucositis occurs is based on the fact that the oral mucosa has a high level of mitotic activity and high cell turnover.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study

Yamauchi

Kogashiwa

Moro

et al. 2014

International Journal of Otolaryngology

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Purpose. One of the common side effects experienced by head and neck cancer patients on chemoradiotherapy is mucositis. Severe mucositis may be controllable by limiting cancer therapy, but it has resulted in decreasing the completion rate of chemoradiotherapy. The efficacy of royal jelly (RJ) as prophylaxis against chemoradiotherapy-induced mucositis was evaluated through clinical scoring of oral and pharyngeal mucositis. Methods. In this randomized, single-blind (physician-blind), clinical trial, 13 patients with head and neck cancer requiring chemoradiation were randomly assigned to two groups. Seven patients assigned to the study group received RJ, and 6 patients were assigned to the control group. RJ group patients took RJ three times per day during treatment. The patients in both groups were evaluated twice a week for the development of mucositis using Common Terminology Criteria for Adverse Events version 3.0. Results. A significant reduction in mucositis was seen among RJ-treated patients compared with controls (P < 0.001). Conclusion. This study demonstrated that prophylactic use of RJ was effective in reducing mucositis induced by chemoradiotherapy in head and neck cancer patients. However, further studies are needed because of the small sample size and the absence of double blinding.

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Section: Discussionmentioning

confidence: 99%

The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study

Yamauchi

Kogashiwa

Moro

et al. 2014

International Journal of Otolaryngology

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“…According to Suresh et al, 3 leukocyte levels below 3,000/μL increase the risk of oral mucositis occurrence, which is further increased in combination with factors such as poor oral hygiene and alcohol and tobacco consumption. In the present study, we did not observe a pattern of mucositis occurrence in patients undergoing HSCT because the degree of mucositis severity was not associated with the counting of leukocytes.…”

Section: Discussionmentioning

confidence: 99%

“…The term implies that cells will return to increase with time. 3 Studies have shown that the occurrence of clinical mucositis occurs inversely to bone marrow function, being higher during the nadir of neutropenia and healing, culminating with the recovery of granulocytes. 3,4 The aim of the present study was to evaluate the occurrence of mucositis and oral candidiasis in patients who underwent Hematopoietic Stem Cell transplantation in the Hospital Erasto Gaertner (HEG, Curitiba, Brazil), and to compare that occurrence with the chemotherapeutic nadir of these patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical assessment of oral mucositis and candidiasis compare to chemotherapic nadir in transplanted patients

et al. 2014

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Oral mucositis is a chief complication in patients undergoing hematopoietic stem cell transplantation (HSCT). It is considered a toxic inflammatory reaction that interferes with the patient's recuperation and quality of life. Oral candidiasis is a common fungal infection observed in dental practice, particularly in immunocompromised patients. The aim of this study was to evaluate the presence of oral mucositis and oral candidiasis in patients who underwent HSCT and their correlation with the chemotherapeutic nadir (lowest possible outcome). We evaluated patients with different diagnoses who underwent HSCT at the Hospital Erasto Gaertner. No chemotherapeutic nadir curves could be associated with mucositis, and patients had different presentations of mucositis. No patient developed oral candidiasis during hospitalization. Together with cell counts, we collected demographic data including age, oral hygiene, habits harmful to health, and the use of oral prostheses. It was observed that patients who smoked cigarettes before hospitalization showed less mucositis, resulting in no feeding problems or other comorbid conditions due to the effect of mucositis. However, the nadir of the chemotherapy curve, in isolation, is not a predictive tool for the appearance (or no appearance) of oral mucositis.

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“…Paragangliomas can arise anywhere in the sympathetic and parasympathetic chain of ganglia with the most common sites in the sympathetic nervous system being para-aortic. Extra-adrenal paragangliomas are also found in the head and neck region (glomus jugulare and carotid body tumors), ampulla of Vater, jejunum, pylorus of stomach, and, rarely, cauda equina [ 2 ], where they may account for up to 3.8% of all tumors in that region [ 3 ]. In the cauda equina region, this tumor presents as an intradural extramedullary mass.…”

Section: Introductionmentioning

confidence: 99%

A Unique Case of an Aggressive Gangliocytic Paraganglioma of the Filum Terminale

Akbik

Floruta

Chohan

et al. 2016

Case Reports in Surgery

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Paragangliomas are rare neuroendocrine tumors that are mostly found in the head and neck. Even less common are gangliocytic variant paragangliomas of the spine for which there are only 7 other documented cases in the literature. We report a case of gangliocytic paraganglioma of the sacral spine in a 68-year-old man. The growth pattern is documented over three years, which to our knowledge has not previously been reported in the literature and is different from the natural history. Clinical, radiological, and pathological characteristics of the tumor are discussed in light of available reports of this rare tumor.

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Risk-scoring system for predicting mucositis in patients of head and neck cancer receiving concurrent chemoradiotherapy [rssm-hn]

Abstract: The current tool is fairly accurate in predicting development of mucositis in head and neck cancer patients on chemoradiotherapy. This will further help clinicians to adopt preventive strategies as well as better counseling.

Cited by 26 publications

References 0 publications

The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study

The Effect of Topical Application of Royal Jelly on Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: A Preliminary Study

Clinical assessment of oral mucositis and candidiasis compare to chemotherapic nadir in transplanted patients

A Unique Case of an Aggressive Gangliocytic Paraganglioma of the Filum Terminale

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