Risk Stratification According to the Prognostic Nutritional Index for Predicting Postoperative Complications After Lung Cancer Surgery

Okada, Satoru; Shimada, Junichi; Teramukai, Satoshi; Kato, Daisuke; Tsunezuka, Hiroaki; Miyata, Natsuki; Ishihara, Shunta; Furuya, Tatsuo; Nakazono, Chiaki; Ishikawa, N.; Inoue, Masayoshi

doi:10.1245/s10434-018-6368-y

Cited by 42 publications

(29 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low PNI has been found to be associated with a poor prognosis of some solid cancers. [7][8][9][10][11][12] However, the role of PNI in initially diagnosed NSCLC patients with bone metastasis remains unclear. Our retrospective study aims to evaluate the prognostic role of PNI in initially diagnosed NSCLC patients with bone metastasis.…”

Section: Introductionmentioning

confidence: 99%

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

Cao

Geng

et al. 2020

Clinical Respiratory J

View full text Add to dashboard Cite

Introduction: Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non-small cell lung cancer patients (NSCLC) with bone metastasis remains unclear. Objective: To explore the prognostic role of PNI in NSCLC patients with bone metastasis. Methods: A retrospective analysis of 259 initially diagnosed NSCLC with bone metastasis was conducted. Univariate and multivariate analysis were used to assess the potential prognostic roles of parameters. Results: The most common symptoms initially presented were cough and chest pain. Two hundred patients (77.2%) received the treatment of bisphosphonates. Patients with low PNI were found in 154 (59.5%) patients. Median survival time for all cases was 286 days. The median OS for patients with low and high PNI was 227 and 389 days, respectively. The 6-month, 1-year and 2-year survival rates for patients with low PNI were 66.2%, 29.9% and 10.4% compared to 79.0%, 52.4% and 26.7% in patients with high PNI level. On univariate analysis, female patients, non-smokers, high PNI and systematic chemotherapy (P < 0.05) were shown to be closely correlated with a better prognosis of NSCLC patients with bone metastasis. Only PNI (P = 0.002), systematic chemotherapy (P = 0.026) and distant metastasis number (P = 0.044) held statistical significance on multivariate analysis. Conclusions: PNI represents a non-invasive, efficiency and convenient biomarker of NSCLC patients with bone metastasis. High PNI, systematic chemotherapy and distant metastasis number <2 are independent positive prognostic factors of NSCLC patients with bone metastasis.

show abstract

Section: Introductionmentioning

confidence: 99%

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

Cao

Geng

et al. 2020

Clinical Respiratory J

View full text Add to dashboard Cite

show abstract

“…The prognostic nutritional index (PNI) is widely utilized and may predict postoperative complications and outcomes in cancer patients. 15 – 17 By using serum albumin concentration and total lymphocyte count, PNI allows for routine and easy assessment of patients’ nutritional status before surgery. 18 However, to our knowledge, there are no studies on the association between PNI and pulmonary complications in patients undergoing radical cystectomy.…”

mentioning

confidence: 99%

Impact of Prognostic Nutritional Index on Postoperative Pulmonary Complications in Radical Cystectomy: A Propensity Score-Matched Analysis

Hong

Park

et al. 2020

Ann Surg Oncol

View full text Add to dashboard Cite

Background Radical cystectomy is a standard treatment for muscle-invasive bladder cancer but frequently entails postoperative pulmonary complications (PPCs). Nutrition is closely associated with postoperative outcomes. Therefore, we evaluated the impact of preoperative prognostic nutritional index (PNI) on PPCs in radical cystectomy. Methods PNI was calculated as 10 × (serum albumin) + 0.005 × (total lymphocyte count). The risk factors for PPCs were evaluated using multivariate logistic regression analysis. A receiver operating characteristic curve analysis of PNI was performed, and an optimal cut-off value was identified. Propensity score-matched analysis was used to determine the impact of PNI on PPCs. Postoperative outcomes were also evaluated. Results PPCs occurred in 112 (13.6%) of 822 patients. Multivariate logistic regression analysis identified PNI, age, and serum creatinine level as risk factors. The area under the receiver operating characteristic curve of PNI for predicting PPCs was 0.714 (optimal cut-off value: 45). After propensity score matching, the incidence of PPCs in the PNI ≤ 45 group was significantly higher compared with the PNI > 45 group (20.8% vs. 6.8%; p < 0.001), and PNI ≤ 45 was associated with a higher incidence of PPCs (odds ratio 3.308, 95% confidence interval 1.779–6.151; p < 0.001). The rates of intensive care unit admission and prolonged (> 2 days) stay thereof were higher in patients who developed PPCs. Conclusions Preoperative PNI ≤ 45 was associated with a higher incidence of PPCs in radical cystectomy, suggesting that PNI provides useful information regarding pulmonary complications after radical cystectomy.

show abstract

“…Furthermore, Okada et al proved that there was a dramatic association between a low PNI score and postoperative complications, regardless of the surgery pattern. They demonstrated that the significance of the PNI as a postoperative complication predictor in patients with NSCLC is similar to that in other initial malignancies (19).…”

mentioning

confidence: 79%

Is the prognostic nutritional index (PNI) a useful predictive marker for postoperative complications after lung surgery?

Li¹

2019

J. Thorac. Dis.

View full text Add to dashboard Cite

Risk Stratification According to the Prognostic Nutritional Index for Predicting Postoperative Complications After Lung Cancer Surgery

Abstract: The PNI could be a useful marker to predict the risk of postoperative complications after lung cancer surgery.

Cited by 42 publications

References 29 publications

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

Impact of Prognostic Nutritional Index on Postoperative Pulmonary Complications in Radical Cystectomy: A Propensity Score-Matched Analysis

Is the prognostic nutritional index (PNI) a useful predictive marker for postoperative complications after lung surgery?

Contact Info

Product

Resources

About