Risk stratification in trauma and haemorrhagic shock: Scoring systems derived from the TraumaRegister DGU®

Wutzler, Sebastian; Maegele, Marc; Wafaisade, Arasch; Wyen, H.; Marzi, Ingo; Lefering, Rolf

doi:10.1016/j.injury.2014.08.014

Cited by 18 publications

(11 citation statements)

References 31 publications

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“…Severe hemorrhagic shock, which is a major cause of morbidity and mortality for patients suffering from trauma, visceral hemorrhage, or major surgery, can lead to myocardial dysfunction [ 1 – 4 ]. The immediate presence of adequate perfusion of the tissue (reperfusion) in patients of hemorrhagic shock is the fundamental goal of acute resuscitation, however it may result in an injury that potentially induces organ dysfunction and death, known as ischemia–reperfusion (I/R) injury [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Analyses of changes in myocardial long non-coding RNA and mRNA profiles after severe hemorrhagic shock and resuscitation via RNA sequencing in a rat model

et al. 2018

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BackgroundIschemia–reperfusion injury has been proven to induce organ dysfunction and death, although the mechanism is not fully understood. Long non-coding RNAs (lncRNAs) have drawn wide attention with their important roles in the gene expression of some biological processes and diseases, including myocardial ischemia–reperfusion (I/R) injury. In this paper, a total of 26 Sprague–Dawley (SD) rats were randomized into two groups: sham and ischemia–reperfusion (I/R) injury. Hemorrhagic shock was induced by removing 45% of the estimated total blood volume followed by reinfusion of shed blood. High-throughput RNA sequencing was used to analyze differentially expressed (DE) lncRNAs and messenger RNAs (mRNAs) in the heart tissue 4 h after reperfusion. Myocardial function was also evaluated.ResultsAfter resuscitation, the decline of myocardial function of shocked animals, expressed by cardiac output, ejection fraction, and myocardial performance index (MPI), was significant (p < 0.05). DE lncRNAs and mRNAs were identified by absolute value of fold change ≥ 2 and the false discovery rate ≤ 0.001. In rats from the I/R injury group, 851 lncRNAs and 1015 mRNAs were significantly up-regulated while 1533 lncRNAs and 1702 m RNAs were significantly down-regulated when compared to the sham group. Among the DE lncRNAs, we found 12 location-associated with some known apoptosis-related protein-coding genes which were up-regulated or down-regulated accordingly, including STAT3 and Il1r1. Real time PCR assays confirmed that the expression levels of five location-associated lncRNAs (NONRATT006032.2, NONRATT006033.2, NONRATT006034.2, NONRATT006035.2 and NONRATT029969.2) and their location-associated mRNAs (STAT3 and Il1r1) in the rats from the I/R injury group were all significantly up-regulated versus the sham group.ConclusionsThe DE lncRNAs (NONRATT006032.2, NONRATT006033.2, NONRATT006034.2 and NONRATT006035.2) could be compatible with their role in myocardial protection by stimulating their co-located gene (STAT3) after hemorrhagic shock and resuscitation. The final prognosis of I/R injury might be regulated by different genes, which is regarded as a complex network.Electronic supplementary materialThe online version of this article (10.1186/s12867-018-0113-8) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Analyses of changes in myocardial long non-coding RNA and mRNA profiles after severe hemorrhagic shock and resuscitation via RNA sequencing in a rat model

et al. 2018

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“…The correction of acidosis requires bleeding control and optimization of tissue oxygenation, initially achieved by the replacement of blood and other fluids [28]. The failure of the normalization of metabolic acidosis for more than 48 hours is usually lethal between 86% and 100% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…In our registry, we have missing data of 66% of base excess and only 10% of these have normalization of base excess due to which it is not possible to know when the patient's acidosis is normalized. That is why despite being an important predictor of survival, it cannot be used [28].…”

Section: Discussionmentioning

confidence: 99%

Missing Variables in Major Trauma Registry of Navarre

B¹,

Fortún²,

Belzunegui³

2016

Intensive & Crit Care

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“…84,96,97 Furthermore, despite low ISS of the patients in the COMBAT and PAMPer trials, mortality was very high compared with the results from the German trauma registry. 98 European centers do not use prehospital blood products with such frequency. 99 The European trauma community has commented on the COMBAT and PAMPer trials: "From a European perspective, the blind prehospital administration of plasma to potentially non-coagulopathic patients with short transportation times cannot be justified.…”

Section: International Trends In Trauma Resuscitation and The Use Of Wbmentioning

confidence: 99%

Whole Blood for Civilian Urban Trauma Resuscitation: Historical, Present, and Future Considerations

Walsh

Fries

Moore

et al. 2020

Semin Thromb Hemost

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Whole blood (WB) has been used for more than a century for far-forward combat resuscitation. Following the Iraq/Afghanistan combat, maritime, and austere environment use of WB for the resuscitation of severely hemorrhaging patients, there has been an increasing use of WB for the civilian urban resuscitation environment population. The impetus for this was not just improved outcomes in far-forward hospitals, which had different populations and different needs than the civilian urban population, but also an application of the lessons suggested by recent 1:1:1 plasma:platelets:packed red cells fixed-ratio studies for patients with massive transfusion needs. Mechanistic, logistic, and standardization concerns have been addressed and are evolving as the WB project advances. A small number of studies have been published on WB in the civilian urban trauma population. In addition, European experience with viscoelastic testing and resuscitation with fibrinogen and prothrombin complex concentrate has provided another viewpoint regarding the choice of resuscitation strategies for severely bleeding trauma patients in urban civilian environments. There are randomized controlled trials in process, which are testing the hypothesis that WB may be beneficial for the civilian urban population. Whether WB will improve mortality significantly is now a matter of intense study, and this commentary reviews the history, mechanistic foundations, and logistical aspects for the use of WB in the civilian trauma population.

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Risk stratification in trauma and haemorrhagic shock: Scoring systems derived from the TraumaRegister DGU®

Cited by 18 publications

References 31 publications

Analyses of changes in myocardial long non-coding RNA and mRNA profiles after severe hemorrhagic shock and resuscitation via RNA sequencing in a rat model

Analyses of changes in myocardial long non-coding RNA and mRNA profiles after severe hemorrhagic shock and resuscitation via RNA sequencing in a rat model

Missing Variables in Major Trauma Registry of Navarre

Whole Blood for Civilian Urban Trauma Resuscitation: Historical, Present, and Future Considerations

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