Risk variables for coronary artery disease in Asian Indians

Ramachandra, Abhay B.; Sathyamurthy, I; Snehalatha, Chamukuttan; Kumpatla, Satyavani; Sivasankari, S.; Misra, Jaya; Girinath, M. R.; Viswanathan, Vijay

doi:10.1016/s0168-8227(00)81038-4

Cited by 8 publications

(10 citation statements)

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“…[14][15][16] The higher incidence of diabetes, low HDL, hypertriglyceridaemia, increased BMI, insulin resistance, and hence the likely presence of M-IRS are consistent risk factors for CHD in migrant Indian Asians. [17][18][19] However, few studies have assessed the utility of current definitions of M-IRS as CHD risk factors in native Indian Asian populations.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and risk of coronary heart disease in a Pakistani cohort

Wierzbicki

Nishtar²,

Lumb³

et al. 2005

Heart

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Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and risk of coronary heart disease in a Pakistani cohort

Wierzbicki

Nishtar²,

Lumb³

et al. 2005

Heart

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“…80 Some of the comparative studies on migrant Indians have suggested that the excess risk for CAD seen among Indians could be partly explained by these risk factors. [81][82][83] Fibrinogen and PAI-1 levels have been found to be associated with angiographically proven CAD, and the relative ORs for CAD increased with increase in quartiles of fibrinogen and PAI-1. 82 A study from South India also showed a weak association of PAI-1 with CAD, 83 while another study on native Indians showed that PAI-1 correlated well with triglycerides.…”

Section: Fibrinolytic Factorsmentioning

confidence: 99%

“…[81][82][83] Fibrinogen and PAI-1 levels have been found to be associated with angiographically proven CAD, and the relative ORs for CAD increased with increase in quartiles of fibrinogen and PAI-1. 82 A study from South India also showed a weak association of PAI-1 with CAD, 83 while another study on native Indians showed that PAI-1 correlated well with triglycerides. 84 85 It can competitively inhibit plasminogen activity, leading to impaired fibrinolysis.…”

Section: Fibrinolytic Factorsmentioning

confidence: 99%

Epidemiology of Cardiovascular Disease in Type 2 Diabetes: The Indian Scenario

Mohan

Venkatraman²,

Pradeepa

2010

J Diabetes Sci Technol

526

575

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Noncommunicable diseases, of which coronary artery disease (CAD) and diabetes top the list, have overtaken communicable diseases with respect to overall mortality, even in developing countries like India. High prevalence rates of diabetes and CAD are seen not only in affluent migrant Indians, but also in those living within the subcontinent. Indeed the epidemic of diabetes and CAD is now spreading to the middle- and lower-income groups in India. The risk for CAD is two to four times higher in diabetic subjects, and in Indians, CAD occurs prematurely, i.e., one to two decades earlier than in the West. Thus there is an urgent need for studies on CAD in diabetic and nondiabetic subjects in India. The Chennai Urban Population Study, a population-based study in Chennai, in South India, showed a prevalence of CAD of 11%, which is 10 times more than what it was in 1970. Clustering of risk factors for CAD such as hyperglycemia, central body obesity, dyslipidemia, and hypertension tends to occur, and interplay of these risk factors could explain the enhanced CAD risk in Indians. Additionally, low-grade inflammation and a possible inherent genetic susceptibility are other contributing factors. Preventive measures such as lifestyle modification with healthy diet, adequate physical activity, and decrease in stress could help prevent the twin epidemics of diabetes and CAD.

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“…An association of IR with CAD was also seen in non‐diabetic subjects12 . Strong association of CAD with dyslipidaemia has been demonstrated in southern Indian subjects13 .…”

Section: Introductionmentioning

confidence: 99%