Risk variables for coronary artery disease in Asian Indians

Ramachandran, Ambady; Sathyamurthy, I; Snehalatha, Chamukuttan; Kumpatla, Satyavani; Sivasankari, S.; Misra, Jaya; Girinath, M. R.; Viswanathan, Vijay

doi:10.1016/s0002-9149(00)01356-4

Cited by 28 publications

(14 citation statements)

References 20 publications

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“…It has been emphasized also that dyslipidaemia is a silent killer and increased the risk to develop CHD prematurely (Enas et al, 2003;Bhalodkar et al, 2004;Yusuf et al, 2004). The prevalence of T2DM and/or dyslipidaemia, on the other hand, are high for Asian Indians both in India (Gupta and Gupta, 1996;Ramachandran et al, 2001;Kutty et al, 2002;Gupta et al, 2004) and abroad (Deurenberg-Yap et al, 2001;Ho et al, 2001;Bhalodkar et al, 2004;Yusuf et al, 2004;Ezenwaka and Kalloo, 2005) and in turn emphasized the effective managements including nutrients profiling to identify individual who are at greater risk from dyslipidaemia and/or T2DM.…”

Section: Introductionmentioning

confidence: 99%

Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects

Ghosh

2006

Eur J Clin Nutr

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Objectives: To compare obesity measures, metabolic profiles and dietary fatty acids in lean and obese dyslipideamic Asian Indian male subjects. Design: Cross-sectional. Settings: Asian Indians living in the eastern part of India. Subjects: One hundred and thirty (Group I: lean control, n ¼ 50; Group II: lean dyslipidaemic, n ¼ 40 and Group III: obese dyslipidaemic, n ¼ 40) Asian Indian male subjects (X30 years) living in the eastern part of India. Methods: Anthropometric measures namely height, weight, circumferences of waist (WC) and hip, lipids (total cholesterol (TC) and triglycerides (TG)), lipoproteins (high-(HDL) and low-density lipoproteins (LDL)), fasting plasma glucose (FPG) and dietary fatty acids were obtained from each participant. Obesity measures, that is, body mass index (BMI), waist-hip ratio (WHR) and conicity index (CI) were subsequently calculated from anthropometric measures. Obesity was defined as individuals having BMIX25 kg/m 2 . Subjects with one or more of the following conditions were considered as dyslipidaemic: TGX2.3 mmol/l, TCX6.2 mmol/l, or TC/HDLX4.4 mmol/l. Daily intake of nutrients as well as saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) were estimated by adding together all the foodstuffs consumed on weekly and monthly manner. Conversion of foodstuffs into nutrients was performed according to standard nutritive values of Indian foodstuffs. Results: Analysis of variance with Scheffe's post hoc test revealed that Group I had significantly lower mean compared to both Group II and Group III for age, WC, WHR, CI, TC, TG, LDL, FPG, total carbohydrates intake and intake of trans fatty acids. On the other hand, Group I had significantly lower mean than Group III only for BMI as well as intake of total proteins, total fats, total energy and erucic acids. Although, Group I had significantly greater mean compared to both Group II and Group III for HDL, UFA/SFA, MUFA/SFA and PUFA/SFA. Pearson's partial correlations (controlling for age and total energy) revealed that central obesity measures (WC, WHR and CI) had significant association with dietary fatty acids and their ratios. Furthermore, partial correlations (controlling for age) also showed that the ratios of unsaturated to SFA had significant negative association with lipids, lipoproteins (except HDL) and plasma glucose. Discriminant function analysis revealed that overall 78% of all entries were positively (correctly) classified in three groups using fatty acids and their ratios. Conclusion: It seems rational to argue that while dealing with dyslipidaemic Asian Indians, clinicians should consider obesity measures, metabolic profiles and dietary fatty acids simultaneously to better comprehend the condition (s).

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Section: Introductionmentioning

confidence: 99%

Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects

Ghosh

2006

Eur J Clin Nutr

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“…In earlier studies of lipids among South Asians, cholesterol levels have been reported to be normal or low (Rajadurai et al, 1992). However, a number of risk factors related to the metabolic syndrome (insulin-resistance syndrome) have been described in South Asians; these include an excess of noninsulindependent diabetes (NIDDM) (Ramachandran et al, 2001), increased upper body obesity with increased waist-to-hip ratio (WHR) (McKeigue et al, 1991), elevated plasma insulin (hyperinsulinaemia) and increased insulin resistance (Laws et al, 1994) all of which influence CHD risk.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Mahajan

Bermingham

2004

Eur J Clin Nutr

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Objective: To identify the prevalence of coronary risk factors among South Asian Indians in Australia and India. Design: Cross-sectional intercountry comparison. Subjects: Healthy volunteers aged 23-75 y recruited from the Indian community in Sydney Australia (n¼125), and their nominated relatives in India, (n¼125). Results: The two groups were of similar background with over 90% of the group in India being siblings, parents or relatives of the group in Australia. There was no difference in the populations between India and Australia with regard to mean age (40711.5 vs 39710. Conclusion:The group in Australia (especially women) have a more favourable disease risk profile than those in India. The fact that the groups are of such similar background and partly related, make it unlikely that changes due to migration have a strong genetic bias. In contrast to other studies, the absence here of excessive weight gain on migration may be a key factor in disease risk prevention.

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“…However, the results from one small case-study have shown that the occurence of CVD in Slovak Roma people is approximately 1.5-fold higher than in the majority population [12]. Moreover, CVD in Roma, as in Asian Indians, is premature, agressive, severe, and more often have dismal prognosis as compared to those occuring in Caucasian patients [13].…”

Section: Introductionmentioning

confidence: 95%

Lipoprotein(a) in Children of Asian Indian Descendants and Their Caucasian Neighbors: The Slovak Lipid Community Study

Alberty

Albertyová

2012

Ind J Clin Biochem

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To elucidate a higher rate of premature cardiovascular disease (CVD) in Asian Indian descendants (Roma) in Slovakia, we investigated frequency distribution, correlates and relationship of lipoprotein(a) [Lp(a)] to family CVD risk factors in Roma children and their Caucasian neighbors. The study sample consisted of 607 healthy children aged 7-18 years (55% Roma, 48% male) as part of the biracial (Roma-Caucasian) Slovak Lipid Community Study. Overall, frequency distribution data of Lp(a) were highly skewed to low concentrations, with markedly higher Lp(a) levels in Roma than in Caucasian children (median and range, mg/dL: 14.5; 0-159.2 vs 6.2; 0-112.3, P \ 0.001), regardless of age and gender. Lp(a) was positively correlated with apo B (0.159, P = 0.004) in Roma, and LDL cholesterol (0.170, P = 0.005) in Caucasian children. In addition, daily income of the family was negatively related with Lp(a) in Roma (-0.134, P = 0.036) while positively in Caucasians (0.136, P = 0.047). For both race groups, no significant association was found between Lp(a) and age, body mass index, mean arterial pressure, smoking, and physical activity. Also, no significant relationships were examined between serum Lp(a) levels [30 mg/dL in children and family CVD risk factors, except for diabetes mellitus in parents of Caucasian origin (OR 4.46;. In a multivariate analysis, daily income, LDL cholesterol or apo B explained *7% of the variance of Lp(a). This study suggests a significantly higher serum Lp(a) levels in Roma than in Caucasian children and a small effect, in general, of relevant CVD risk factors on the variation of Lp(a) levels in childhood.

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Risk variables for coronary artery disease in Asian Indians

Cited by 28 publications

References 20 publications

Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects

Comparison of anthropometric, metabolic and dietary fatty acids profiles in lean and obese dyslipidaemic Asian Indian male subjects

Risk factors for coronary heart disease in two similar Indian population groups, one residing in India, and the other in Sydney, Australia

Lipoprotein(a) in Children of Asian Indian Descendants and Their Caucasian Neighbors: The Slovak Lipid Community Study

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