Risks of maternal prepregnancy overweight/obesity, excessive gestational weight gain, and bottle-feeding in infancy rapid weight gain: evidence from a cohort study in China

Yang, Shuai; Hong, Ming; Hui, Mei; Yang, Yan; Li, Na; Tan, Yafei; Zhang, Yiming; Zhang, Dan; Zhang, Yan; Peng, Anna; Zhang, Bin

doi:10.1007/s11427-018-9831-5

Cited by 20 publications

(24 citation statements)

References 33 publications

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“…Since only paternal BMI but both maternal and paternal weight showed significant association with RWG, and maternal weight gain also was included as another potential risk factor, the weight values were used in the predictive models. Male sex, maternal smoking, maternal overweight before pregnancy, excess maternal gestational weight gain, paternal overweight and low or high birth weight in the infant have all been associated with RWG and overweight or obesity in previous research [3,8,9,13]. Paternal smoking and parental education were examined as indicators of socioeconomic level since low socioeconomic level has been associated with RWG [3,15].…”

Section: Definition Of Rapid Weight Gainmentioning

confidence: 99%

“…Observed risk factors for rapid weight gain operates both before and during pregnancy as well as early in life. These include maternal pre-pregnancy overweight [8][9][10][11][12] and excessive maternal gestational weight gain [9][10][11], maternal and paternal overweight [8], maternal smoking during pregnancy [8,13], maternal smoking after birth or history of smoking [13], smoking in the same room as the child [8], male sex in the child [13,14], younger gestational age, first born status [13] and low socioeconomic status [15]. Besides these risk factors, a number of nutrition-or feeding practice-related factors acting early in life have been associated with RWG [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Nutrition- and feeding practice-related risk factors for rapid weight gain during the first year of life: a population-based birth cohort study

et al. 2020

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Background Rapid weight gain (RWG) during infancy increases the risk of excess weight later in life. Nutrition- and feeding practices associated with RWG need to be further examined. The present study aimed to examine nutrition- and feeding practice-related risk factors for RWG during the first year of life. Methods A population-based longitudinal birth cohort study of 1780 infants, classified as having RWG or non-RWG during 0–3-4, 0–6 and 6–12 months. RWG was defined as a change > 0.67 in weight standard deviation scores. Associations between nutrition- and feeding practice-related factors and RWG were examined with logistic regression models. Results Of the participating infants, 47% had RWG during 0–3-4 months, 46% during 0–6 months and 8% during 6–12 months. In the fully adjusted models, bottle-feeding at birth and at 3–4 months and nighttime meals containing formula milk were positively associated with RWG during 0–3-4 months (p < 0.05 for all). Breastfeeding at 3–4 months and nighttime meals containing breast milk were negatively associated with RWG during this period (p < 0.001). Bottle-feeding at birth, 3–4 and 6 months and nighttime meals containing formula milk at 3–4 months were positively associated with RWG during 0–6 months (p < 0.01 for all). Breastfeeding at 3–4 and 6 months was negatively associated with RWG (p < 0.01). During 6–12 months, only bottle-feeding at 3–4 months was positively associated with RWG (p < 0.05). Conclusions RWG was more common during the first 6 months of life and bottle-feeding and formula milk given at night were risk factors for RWG during this period.

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Section: Definition Of Rapid Weight Gainmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nutrition- and feeding practice-related risk factors for rapid weight gain during the first year of life: a population-based birth cohort study

et al. 2020

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“…For instance, Tianjin is one of the cities most affected by air pollution as a result of rapid industrialization and urbanization. It is also a typical city in China facing the problems of population aging and advanced maternal age; (2) Tianjin has developed a three-tier antenatal healthcare system, which is effective in organizing population-based cohort projects; (3) Although several birth cohorts have been set up in Guangzhou and several other cities [9][10][11]20 in China, there is a lack of a large cohort in the northern part of China. Tianjin is 120 kilometers away from Beijing, with a relatively developed economy 12 and large population, which provides a good foundation for large-scale population studies in northern China; (4) Tianjin has regional health problems, such as high prevalence of gestational diabetes mellitus (GDM; 9.3% in 2012) 13 and childhood obesity (16.3% in 2014) comparing with other Chinese cities.…”

Section: Introductionmentioning

confidence: 99%

Study Design and Baseline Profiles of Participants in the Tianjin Birth Cohort (TJBC) in China

Wang

Zhang

Wang

et al. 2022

Journal of Epidemiology

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Background: To investigate the causal link between early-life exposures and long-term health consequences, we established the Tianjin Birth Cohort (TJBC), a large-scale prospective cohort in northern China. Methods: TJBC aims to enroll 10,000 families with follow-ups from pregnancy until children's six year-old. Pregnant women and their spouses were recruited through a three-tier antenatal healthcare system at early pregnancy, with follow-ups at midpregnancy, late pregnancy, delivery, 42 days after delivery, 6 months after delivery, and each year until 6 years old. Antenatal= neonatal examination, biological samples and questionnaires were collected. Results: From August 2017 to January 2019, a total of 3,924 pregnant women have already been enrolled, and 1,697 women have given birth. We observed the prevalence of gestational diabetes mellitus as 18.1%, anemia as 20.4%, and thyroid hypofunction as 2.0%. In singleton live births, 5.6% were preterm birth (PTB), 3.7% were low birth weight, and 7.3% were macrosomia. Based on current data, we also identified maternal=paternal factors which increased the risk of PTB, including paternal age (OR 1.07; 95% CI, 1.01-1.14 for each year increase), vaginal bleeding during pregnancy (OR 2.82; 95% CI, 1.54-5.17) and maternal early-pregnancy BMI (OR 1.08; 95% CI, 1.01-1.15 for each kg=m 2 increase). Conclusion: TJBC has the strength of collecting comprehensive maternal, paternal, and childhood information. With a diverse range of biological samples, we are also engaging with emerging new technologies for multi-omics research. The study would provide new insight into the causal link between macro=micro-environmental exposures of early life and short=long-term health consequences.

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“…Also, patient 288417 showed a core phenotype characterized by obesity, aggressive behavior, intellectual disability, and psychosis (information of infant period was not provided), pointing toward a causative role of the genes in the minimal critical region in the broader phenotype of typical PWS. Furthermore, in animal models of PWS, knockout Snord116 mice displayed cognitive deficits ( Adhikari et al, 2019 ), growth retardation ( Ding et al, 2008 ), hyperphagia, and marked obesity ( Polex-Wolf et al, 2018 ; Yang et al, 2019 ). So, all these findings indicate that PWS with microdeletion disrupting the IC should be considered in patients with hypotonia and developmental delay, even in the absence of the striking facial features.…”

Section: Discussionmentioning

confidence: 99%

Transmission of a Novel Imprinting Center Deletion Associated With Prader–Willi Syndrome Through Three Generations of a Chinese Family: Case Presentation, Differential Diagnosis, and a Lesson Worth Thinking About

Zhang

Liu

et al. 2021

Front. Genet.

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Prader–Willi syndrome (PWS) is a complex genetic syndrome caused by the loss of function of genes in 15q11-q13 that are subject to regulation by genomic imprinting and expressed from the paternal allele only. The main clinical features of PWS patients are hypotonia during the neonatal and infantile stages, accompanied by delayed neuropsychomotor development, hyperphagia, obesity, hypogonadism, short stature, small hands and feet, mental disabilities, and behavioral problems. However, PWS has a clinical overlap with other disorders, especially those with other gene variations or chromosomal imbalances but sharing part of the similar clinical manifestations with PWS, which are sometimes referred to as Prader–Willi syndrome-like (PWS-like) disorders. Furthermore, it is worth mentioning that significant obesity as a consequence of hyperphagia in PWS usually develops between the ages of 1 and 6 years, which makes early diagnosis difficult. Thus, PWS is often not clinically recognized in infants and, on the other hand, may be wrongly suspected in obese and intellectually disabled patients. Therefore, an accurate investigation is necessary to differentiate classical PWS from PWS-like phenotypes, which is imperative for further treatment. For PWS, it is usually sporadic, and very rare family history and affected siblings have been described. Here, we report the clinical and molecular findings in a three-generation family with a novel 550-kb microdeletion affecting the chromosome 15 imprinting center (IC). Overall, the present study finds that the symptoms of our patient are somewhat different from those of typical PWS cases diagnosed and given treatment in our hospital. The familial occurrence and clinical features were challenging to our diagnostic strategy. The microdeletion included a region within the complex small nuclear ribonucleoprotein polypeptide protein N (SNRPN) gene locus encompassing the PWS IC and was identified by using a variety of techniques. Haplotype studies suggest that the IC microdeletion was vertically transmitted from an unaffected paternal grandmother to an unaffected father and then caused PWS in two sibling grandchildren when the IC microdeletion was inherited paternally. Based on the results of our study, preimplantation genetic diagnosis (PGD) was applied successfully to exclude imprinting deficiency in preimplantation embryos before transfer into the mother’s uterus. Our study may be especially instructive regarding accurate diagnosis, differential diagnosis, genetic counseling, and PGD for familial PWS patients.

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Risks of maternal prepregnancy overweight/obesity, excessive gestational weight gain, and bottle-feeding in infancy rapid weight gain: evidence from a cohort study in China

Cited by 20 publications

References 33 publications

Nutrition- and feeding practice-related risk factors for rapid weight gain during the first year of life: a population-based birth cohort study

Nutrition- and feeding practice-related risk factors for rapid weight gain during the first year of life: a population-based birth cohort study

Study Design and Baseline Profiles of Participants in the Tianjin Birth Cohort (TJBC) in China

Transmission of a Novel Imprinting Center Deletion Associated With Prader–Willi Syndrome Through Three Generations of a Chinese Family: Case Presentation, Differential Diagnosis, and a Lesson Worth Thinking About

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