Risky decision-making in individuals with substance use disorder: A meta-analysis and meta-regression review

Chen, Shujuan; Yang, Pengbo; Chen, Tianzhen; Su, Hang; Jiang, Haifeng; Zhao, Min

doi:10.1007/s00213-020-05506-y

Cited by 58 publications

(42 citation statements)

References 101 publications

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“…The current findings are in line with previous research showing that higher levels of alcohol consumption are associated with increased risk-taking behavior and more frequently experiencing negative alcohol-related consequences [ 6 , 7 , 8 , 9 , 10 ]. The findings are also in agreement with previous meta-analyses showing that individuals who consume AMED do not consume more alcohol on AMED occasions compared to AO occasions [ 26 , 27 , 28 ].…”

Section: Discussionsupporting

confidence: 93%

“…The overall effects include greater disinhibitory effects resulting in an increased propensity for risk-taking behaviors and alcohol-related harm. Indeed, scientific research has consistently shown that higher levels of alcohol consumption are associated with increased risk-taking behavior and more frequently experiencing negative alcohol-related consequences [ 6 , 7 , 8 , 9 , 10 ]. Some risky behaviors associated with alcohol-related consequences include driving under the influence of alcohol [ 11 , 12 ], drinking until blacking out [ 13 ], increased violence or aggression [ 14 , 15 ], sexual risk-taking [ 16 ] and other risks that may lead to injury [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Risk-Taking Behavior and the Consumption of Alcohol Mixed with Energy Drink among Australian, Dutch and UK Students

Johnson

Benson

Scholey

et al. 2021

IJERPH

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The relationship between risk-taking behavior, alcohol consumption and negative alcohol-related consequences is well known. The current analyses were conducted to investigate whether alcohol mixed with energy drink (AMED) is related to risk-taking behavior and if there is a relationship between the amount of energy drink mixed with alcohol consumed, risk-taking behavior and negative alcohol-related consequences. Data from N = 1276 AMED consuming students from the Netherlands, UK and Australia who completed the same survey were evaluated. The analysis revealed that, compared to AMED occasions, on alcohol only (AO) occasions significantly more alcohol was consumed and significantly more negative alcohol-related consequences were reported. On both AO and AMED occasions, there was a strong and positive relationship between amount of alcohol consumed, level of risk-taking behavior and number of reported negative alcohol-related consequences. In contrast, the level of risk-taking behavior was not clearly related to energy drink consumption. Across risk-taking levels, differences in the amount of energy drink consumed on AMED occasions did not exceed one 250 mL serving of energy drink. When correcting for the amount of alcohol consumed, there were no statistically significant differences in the number of energy drinks consumed on AMED occasions between the risk-taking groups. In conclusion, alcohol consumption is clearly related to risk-taking behavior and experiencing negative alcohol-related consequences. In contrast, energy drink intake was not related to level of risk-taking behavior and only weakly related to the number of experienced negative alcohol-related consequences.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Risk-Taking Behavior and the Consumption of Alcohol Mixed with Energy Drink among Australian, Dutch and UK Students

Johnson

Benson

Scholey

et al. 2021

IJERPH

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“…This experiment is the first to examine the effects of EGCG on risk-taking, as well as the acute effects of caffeine and joint EGCG/caffeine. The results suggest EGCG as a potential therapeutic treatment for psychological disorders that induce compulsive risky decision-making, such as bipolar disorder, schizophrenia, and substance use disorder (Reddy et al, 2013; Chen et al, 2020). Notably, these effects are nullified when EGCG is given in conjunction with caffeine, suggesting that EGCG must be isolated from green tea to impact cost-benefit decision-making.…”

Section: Discussionmentioning

confidence: 96%

The effects of epigallocatechin gallate and caffeine on risky decision-making

Dbk

et al. 2021

Preprint

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Epigallocatechin-3-gallate (EGCG) and caffeine are the two primary compounds found in green tea. While EGCG has anxiolytic and anti-inflammatory effects, its acute effects on cognition are not well understood. Furthermore, despite widespread green tea consumption, little is known about how EGCG and caffeine co-administration impact behavior. Here, we investigated the effects of multiple doses of either EGCG or caffeine on a rat model of risk-taking. This was assessed using the risky decision-making task (RDT), in which rats choose between a small, safe reward and a large reward with escalating risk of mild footshock. Rats were tested in RDT after acute systemic administration of EGCG, caffeine, or joint EGCG and caffeine. EGCG caused a dose dependent reduction in risk-taking without affecting reward discrimination or task engagement. Caffeine did not impact risk taking, but elevated locomotor activity and reduced task engagement at high doses. Finally, exposure to both EGCG and caffeine had no effect on risk-taking, suggesting that low-dose caffeine is sufficient to mask the risk-aversion caused by EGCG. These data suggest EGCG as a potential therapeutic treatment for psychological disorders that induce compulsive risky decision-making.

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“…The amount of points gained or lost consisted in the amount of points betted by the participants. Outcome domain measures for this task consisted in the multiple facets of the risky decision-making process commonly manifested by substance users (6,16,31). Specifically, outcome measures consisted in (a) the average number of points betted after choosing the most likely outcome (risk taking score); (b) the overall proportion of points betted during the task (overall proportion bet score) [both (a) and (b) outcome measures reflect a propensity toward risk]; (c) the proportion of all trials where the subject chose the majority box color, which reflects the rationality of the participants' decision making process (quality of decision making score); and (d) the ability to modify choices in light of information about the probability of different outcomes (risk adjustment score) (6,16,31).…”

Section: Cognitive Measuresmentioning

confidence: 99%

“…Notably, impairments in the neuropsychological domain of "cognitive impulsivity" constitute one of the main features of substance users (2)(3)(4)(5), including chronic tobacco smokers (6)(7)(8). Particularly, impairments in cognitive impulsivity are considered relevant for the initiation and chronicity of substance use (5).…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical Correlates of Impulsive Choices and Risky Decision Making in Young Chronic Tobacco Smokers: A Voxel-Based Morphometry Study

Conti

Baldacchino

2021

Front. Psychiatry

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Introduction: Impairments in the multifaceted neuropsychological construct of cognitive impulsivity are a main feature of chronic tobacco smokers. According to the literature, these cognitive impairments are relevant for the initiation and maintenance of the smoking behavior. However, the neuroanatomical correlates of cognitive impulsivity in chronic smokers remain under-investigated.Methods: A sample of 28 chronic smokers (mean age = 28 years) not affected by polysubstance dependence and 24 matched non-smoker controls was recruited. Voxel Based Morphometry (VBM) was employed to assess Gray Matter (GM) volume differences between smokers and non-smokers. The relationships between GM volume and behavioral manifestations of impulsive choices (5 trial adjusting delay discounting task, ADT-5) and risky decision making (Cambridge Gambling Task, CGT) were also investigated.Results: VBM results revealed GM volume reductions in cortical and striatal brain regions of chronic smokers compared to non-smokers. Additionally, smokers showed heightened impulsive choices (p < 0.01, Cohen's f = 0.50) and a riskier decision- making process (p < 0.01, Cohen's f = 0.40) compared to non-smokers. GM volume reductions in the left Anterior Cingulate Cortex (ACC) correlated with impaired impulsive and risky choices, while GM volume reductions in the left Ventrolateral Prefrontal Cortex (VLPFC) and Caudate correlated with heightened impulsive choices. Reduced GM volume in the left VLPFC correlated with younger age at smoking initiation (mean = 16 years).Conclusion: Smokers displayed significant GM volume reductions and related cognitive impulsivity impairments compared to non-smoker individuals. Longitudinal studies would be required to assess whether these impairments underline neurocognitive endophenotypes or if they are a consequence of tobacco exposure on the adolescent brain.

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Risky decision-making in individuals with substance use disorder: A meta-analysis and meta-regression review

Cited by 58 publications

References 101 publications

Risk-Taking Behavior and the Consumption of Alcohol Mixed with Energy Drink among Australian, Dutch and UK Students

Risk-Taking Behavior and the Consumption of Alcohol Mixed with Energy Drink among Australian, Dutch and UK Students

The effects of epigallocatechin gallate and caffeine on risky decision-making

Neuroanatomical Correlates of Impulsive Choices and Risky Decision Making in Young Chronic Tobacco Smokers: A Voxel-Based Morphometry Study

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