Risperidone and Hyponatremia: a Case Report

Whitten, James E.; Ruehter, Valerie L.; Pharm, B. S.

doi:10.3109/10401239709147795

Cited by 33 publications

(22 citation statements)

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“…Previous studies suggest that conventional antipsychotics such as haloperidol may be associated with inappropriate ADH secretion and atypicals such as clozapine may reverse it (Rider et al, 1995;Canuso and Goldman, 1999). One case on risperidone (but none on olanzapine) was reported to be linked to hyponatremia (Whitten and Ruehter, 1997). In our study, eight of 16 subjects with schizophrenia had received treatment with olanzapine or risperidone prior to scanning, and the remaining 8 had not received antipsychotic treatment.…”

Section: Discussionmentioning

confidence: 50%

CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia

Gunduz‐Bruce

Narr

Gueorguieva

et al. 2007

Psychiatry Research: Neuroimaging

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Preliminary evidence suggests that plasma Na + level/osmolality may have effects on brain morphology; thus we investigated the link between plasma osmolality and ventricle size in healthy controls and patients with first episode schizophrenia. A total of 16 patients and 28 healthy controls were examined with magnetic resonance imaging (MRI) and gave blood samples. Highresolution 3D SPGR images were obtained on a 1.5 Tesla scanner. Scalp-edited MRI volumes were used for estimates of intracranial gray, white matter and CSF. Regional changes in CSF concentration and ventricular morphology were measured. The groups did not differ in plasma osmolality, but patients had higher plasma Na + . There were no differences in ventricle size. Controlling for plasma osmolality did not change the results. A mixed model procedure indicated a significant group effect and a significant osmolality by group interaction in ventricle measures. Healthy control group showed a significant relationship between osmolality and ventricle measures; this relationship was absent in the patients. Significant correlations between osmolality and lateral ventricle surface deformations were observed along the superior horn of the lateral ventricles in the healthy controls. These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia.

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Section: Discussionmentioning

confidence: 50%

CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia

Gunduz‐Bruce

Narr

Gueorguieva

et al. 2007

Psychiatry Research: Neuroimaging

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“…There have been 2 reported cases each of aripiprazole, 4,9 quetiapine, 1,10 clozapine, 11 and risperidone. 8,12 There has been 1 reported case with olanzapine 13 and ziprasidone. 14 Although the onset time between initiating the medication and the hyponatremia was 7-50 days for other atypical antipsychotics, it has been about 4 days in the aripiprazole-induced cases.…”

Section: Discussionmentioning

confidence: 97%

Antipsychotic-Induced Hyponatremia: Case Report and Literature Review

Kohen¹,

Voelker

Manu

2008

American Journal of Therapeutics

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We report a case of hyponatremia in a patient that occurred 3 days after initiation of treatment with aripiprazole. The patient was a 50-year-old man admitted to an inpatient psychiatric unit for exacerbation of schizophrenia. He was started on aripiprazole and developed hyponatremia that resolved when the medication was stopped. We postulate that the hyponatremia was due to an aripiprazole-induced syndrome of inappropriate secretion of antidiuretic hormone. There have been numerous case reports in the literature of hyponatremia in the literature associated with atypical antipsychotics. We caution clinicians to be aware that the potential hyponatremic-inducing effects of atypical antipsychotics can occur rapidly after initiation of the medications.

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“…Psychiatric disorders and psychotropic drugs can cause abnormal sodium value 15 . Many drugs can cause hyponatremia-haloperidol 16 , risperidone 17 , carbamazepine 18 , sodium valproate 19 , tricyclic antidepressants 20 , venlafaxine 21 ; selective serotonin reuptake inhibitors (SSRIs) 22 .Similarly screening for hypokalemia/hyperkalemia is also of value since ECT is not done without normal value as abnormal values cardiac conduction defects, as shown in various studies 14,23 . Abnormalities in hemoglobin and other hematological parameters did not predicted complications of ECT.…”

Section: Discussionmentioning

confidence: 99%

Laboratory screening prior to modified electroconvulsive therapy

Adhikari

2015

J Chitwan Med Coll

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Laboratory screening for subtle medical disease is critical prior to modified electroconvulsive therapy (MECT). It is important to rule out medical condition since MECT is performed under general anesthesia. 25 patients planned for MECT were evaluated with complete blood count, hemoglobin, serum sodium, serum potassium, serum creatin, blood sugar, electrocardiogram (ECG), chest radiograph(X-ray chest). Investigations showed some abnormal values in blood sugar, serum sodium, serum potassium, ECG and X-ray chest. Proper guideline is needed for evaluation of patients who undergo MECT. Medical conditions along with other subtle diseases are important to rule out before undergoing MECT.

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Risperidone and Hyponatremia: a Case Report

Cited by 33 publications

References 0 publications

CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia

CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophrenia

Antipsychotic-Induced Hyponatremia: Case Report and Literature Review

Laboratory screening prior to modified electroconvulsive therapy

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