Risperidone-Associated Rhabdomyolysis Without Neuroleptic Malignant Syndrome

Look, Mei Ling; Boo, Yang Liang; Chin, Pek Woon; Hoo, Fan Kee

doi:10.1097/jcp.0000000000000614

Cited by 8 publications

(2 citation statements)

References 12 publications

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“… 1 Levenson 1 has reported two NMS cases with CK levels exceeding 50,000 IU/L and a case with 100,000 IU/L following chlorpromazine- and benztropine mesylate-induced rhabdomyolysis without NMS. Look et al 15 reported a case with a CK of 73,780 IU/L due to risperidone-induced rhabdomyolysis, but without NMS. Meltzer et al 9 reported 11 cases of markedly elevated CK activity with various antipsychotic drugs in the absence of NMS, where a young female had 177,000 IU/L of CK following loxapine treatment, and the peak level of CK following risperidone treatment was 9571 IU/L.…”

Section: Discussionmentioning

confidence: 99%

Exceptionally high creatine kinase levels in risperidone-induced neuroleptic malignant syndrome: A case report

Ozaal

Katulanda

2022

SAGE Open Medical Case Reports

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Neuroleptic malignant syndrome is a rare, fatal antipsychotic-induced idiosyncratic reaction characterised by hyperthermia, altered consciousness, autonomic instability and rigidity with elevated creatine kinase levels and leukocytosis. Neuroleptic malignant syndrome and antipsychotics are significant causes for elevated creatine kinase among the extensive list of differential diagnoses. Risperidone is an atypical antipsychotic drug with anti-serotonergic and anti-dopaminergic properties which has a wide range of side effects, including neuroleptic malignant syndrome. Though the rise in creatine kinase in neuroleptic malignant syndrome is commonly around 2000 to 15,000 IU/L due to myonecrosis, ischaemia and heat production, normal creatine kinase levels in neuroleptic malignant syndrome were also reported. Up to now, only two cases have been reported with creatine kinase levels of more than 50,000 IU/L in neuroleptic malignant syndrome, but neither of them was risperidone-induced. We report the first case of an exceptional rise in creatine kinase levels more than 250-fold in a 16-year-old girl following low-dose risperidone-induced neuroleptic malignant syndrome.

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Section: Discussionmentioning

confidence: 99%

Exceptionally high creatine kinase levels in risperidone-induced neuroleptic malignant syndrome: A case report

Ozaal

Katulanda

2022

SAGE Open Medical Case Reports

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“…This is particularly important because it can lead to severe acute kidney injury with possible life-threatening complications. 2…”

Section: Rhabdomyolysis Caused By Risperidonementioning

confidence: 99%

ISMP Adverse Drug Reactions: Allergic Angina Caused by Fluconazole Rhabdomyolysis Caused by Risperidone High Incidence of Hyponatremia With High-Dose Trimethoprim-Sulfamethoxazole Lithium Carbonate-Induced Hypersalivation Persistent Hemorrhage After Idarucizumab Administration

Mancano

2017

Hosp Pharm

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The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Institute for Safe Medication Practices (ISMP) in cooperation with the FDA's MedWatch program and Temple University School of Pharmacy. ISMP is an FDA MedWatch partner.

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Rhabdomyolysis after risperidone

Lam¹

2017

The Brown University Psychopharmacology Update

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Risperidone-Associated Rhabdomyolysis Without Neuroleptic Malignant Syndrome

Cited by 8 publications

References 12 publications

Exceptionally high creatine kinase levels in risperidone-induced neuroleptic malignant syndrome: A case report

Exceptionally high creatine kinase levels in risperidone-induced neuroleptic malignant syndrome: A case report

ISMP Adverse Drug Reactions: Allergic Angina Caused by Fluconazole Rhabdomyolysis Caused by Risperidone High Incidence of Hyponatremia With High-Dose Trimethoprim-Sulfamethoxazole Lithium Carbonate-Induced Hypersalivation Persistent Hemorrhage After Idarucizumab Administration

Rhabdomyolysis after risperidone

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