Risperidone-induced acromegaly: a case report

Abstract

Today, considering their adverse side effects, the first-generation antipsychotics have been replaced by the new-generation antipsychotics (also known as second-generation antipsychotic agents). The superiority of new-generation antipsychotics compared with firstgeneration antipsychotic agents in terms of side effects, especially movement disorders, are acknowledged by clinicians. But in recent years during the use of second-generation antipsychotic agents, endocrine side effects have been noteworthy. In our study with a diagnosis of paranoid schizophrenia treated with risperidone for 14 years and operated with the diagnosis of pituitary macroadenoma, a 32-year-old female patient is presented in the light of the literature examining the framework of the history of disease.

Case report: Treatment of psychiatric symptoms for an acromegalic patient with pituitary adenoma

“…Prior studies have shown that some acromegalic cases initially present with mental disorders long before being diagnosed and treat with antipsychotics, some of which might promote the disease progression. Koroglu et al reported a case of paranoid schizophrenia who was prescribed risperidone for 14 years and was finally diagnosed of acromegaly with pituitary macroadenoma ( 19 ). Iglesias et al also reported three cases of schizophrenic patients treated with antipsychotics (paliperidone, amisulpride, clozapine, and haloperidol) for several years who finally developed acromegaly due to a GH-secreting pituitary macroadenoma ( 20 ).…”

Curious Cases: Acromegaly and Schizophrenia: An Incidental Association?

“…Since its first description by Hofmann in 1953, 3 the association of acromegaly and schizophrenia has been exceptionally reported. [4][5][6][7][8] Some of these patients were not under DA agonist therapy when developed psychiatric symptoms, but they had been treated with antipsychotic drugs, such as haloperidol, 6 olanzapine, 7 and risperidone 8 before acromegaly diagnosis. We are aware that the number of reported cases so far has been scarce, although it could be related to the low prevalence of both clinical entities, especially of acromegaly.…”

“…3 So far, this association has been exceptionally documented. [4][5][6][7][8] We herein report 3 new acromegalic patients with schizophrenia and discuss the possible relationship between both clinical entities.…”