Risperidone-induced pretibial edema: A case report

Gündoğmuş, İbrahim; Unsal, Cansu; Akgün, Abdullah; Bolu, Abdullah; Çeli̇k, Cemi̇l; Uzun, Özcan

doi:10.5455/annalsmedres.2019.10.648

Cited by 2 publications

(4 citation statements)

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“…In the existing study it has been shown that the apparent renal failure was noted as a potential side effect of anorexia nervosa; nevertheless, renal failure and pyelonephritis were identified as the primary disorders and therefore considered independent of psychopathological symptoms. 12,17 The symptoms reported in our case were comparable to those previously described, and Raynaud's disease was found to be associated with AN early in three clinical cases. patients with AN exhibited higher skin sensitivity, however the exact cause of the association between AN and Raynaud's syndrome is still unknown.…”

Section: Discussionsupporting

confidence: 89%

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Pathophysiological Electrolyte Changes Connoted via Antagonism of Serotonin Receptor in Experimental Animals

Mahmood¹,

Younes²,

Saarti³

2022

Pharmacogn J.

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Background: Atypical antipsychotics are a subclass of antipsychotics that have emerged primarily since the 1970s for the treatment of psychiatric disorders. They are sometimes referred to as second-generation antipsychotics (SGAs). Several atypical antipsychotics have received regulatory approval for the treatment of disorders such as bipolar disorder, schizophrenia, irritability in autism, and as adjunctive treatment for major depressive disorders. Objectives: The purpose of the following study was to evaluate the effect of two widely known atypical antipsychotics, aripiprazole, and risperidone, on pathophysiological fluctuations in electrolytes. Several other studies were based on the following ideas, which brought a variety of different perspectives. As can be seen in the following evaluation, although atypical antipsychotics reduce the chance of extrapyramidal symptoms, it leads to impairment of renal function and destruction of renal histo-morphology. Materials and Methods: Thirty rats (10 per group) were used for this study, control group received normal saline, aripiprazole group received 10mg/kg//day, and risperidone group received 20mg/kg//day. The duration of therapy was long up to 3 months. Results: the results confirmed that both drugs reduced plasma sodium and chloride concentration with no effects on plasma potassium and calcium concentration. Moreover, the histomorphology at microscopic level shown no defects after 3 months of therapy. Conclusion: the outcome confirmed no deleterious defects associated with aripiprazole and risperidone when used for 3 months.

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Section: Discussionsupporting

confidence: 89%

“…antipsychotics. 12 There may be significant weight gain. Critics say the distinction between first-and second-generation antipsychotics is unnecessary and should be abandoned.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiological Electrolyte Changes Connoted via Antagonism of Serotonin Receptor in Experimental Animals

Mahmood¹,

Younes²,

Saarti³

2022

Pharmacogn J.

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“…Thyroid dysfunction is relatively common in patients with schizophrenia and other chronic depressive disorders, possibly due to the genetic relationship between these disorders and antipsychotic medications. 18 Many medications do interfere with biochemistry of thyroid function by interfering with the synthesis, transport and metabolism of thyroid hormones, or by altering the synthesis and secretion of thyroxine. Most patients with abnormal thyroid function tests are found to be clinically absent; however, these effects cause overt, clinically apparent thyroid disease in only rare cases.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, it has been increasingly used in the treatment of various psychiatric disorders. 12,13 It is classified as an atypical antipsychotic and belongs to a new chemical class, namely benzisoxazole derivatives. Although risperidone has fewer extrapyramidal side effects than older neuroleptic drugs, it appears to have a greater potential to cause hyperprolactinemia.…”

Section: Introductionmentioning

confidence: 99%