Risque allergique en anesthésie

Mertès, Paul-Michel; Blay, F. De; Dong, Siwei

doi:10.1016/j.lpm.2012.04.026

Cited by 6 publications

(3 citation statements)

References 68 publications

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“…The incidence of anaphylaxis is estimated between 1 in 10,000 and 1 in 20,000 anesthetic procedures [ 2 , 3 ]. However, anaphylactic reactions cannot be clinically distinguished from non-immune mediated reactions which account for 30–40% of hypersensitivity reactions [ 1 , 8 ].…”

Section: Incidencementioning

confidence: 99%

“…The potential occurrence of hypersensitivity reactions (IgE-mediated or non-IgE-mediated) is a great concern for anesthesiologists, because adverse reactions (ARs) may be very severe and life-threatening, with a mortality rate ranging from 3 to 9% [ 1 ]. Fatal anaphylaxis as well as a great proportion of less severe anaphylactic reactions is caused by drugs and substances related to general anesthesia [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Focus on the agents most frequently responsible for perioperative anaphylaxis

et al. 2018

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Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). All these substances (i.e. NMBA, anesthetics, antibiotics, latex devices) may cause severe systemic non-IgE-mediated reactions or fatal anaphylactic events even in the absence of any evident risk factor in the patient’s anamnesis. For this reason, in order to minimize perioperative anaphylactic reactions, it is important to have rapid, specific, sensitive in vitro diagnostic tests able to confirm the clinical diagnosis of acute anaphylaxis.

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Section: Incidencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Focus on the agents most frequently responsible for perioperative anaphylaxis

et al. 2018

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“…If neuromuscular blockers have been administered during the event, they should be excluded due to high rate of cross-reactivity, unless its administration is absolutely mandatory. Remember that cross-reactivity is more frequent among amino steroid blockers than among benzylisoquinoline derivatives 96 and that pancuronium (which has an inflexible structure) appears to be less likely to have cross-reactivity with other amino-steroids. For patients who suffered anaphylaxis with rocuronium and vecuronium, cisatracurium was found to be the agent that had the lowest rate of cross-reactivity to them 97 ;…”

Section: Appendixmentioning

confidence: 99%