What happens when researchers based in the Global North are suddenly unable to access research sites, especially those in the Global South? In 2020, COVID-related public health measures and travel restrictions made clear how dependent certain categories of researchers in the North are on easy access to research sites in the South. The space opened up by their pandemic-imposed retreat and the solutions devised in response have provoked both challenges and opportunities. In this article, we reflect on this space, focusing on how forms of more just collaboration become possible when the inertia of Global North-controlled research is interrupted. Many scholars have argued for change in how Global North-South scholarly collaborations proceed, seeking to root out colonial practices and attend to power imbalances that disadvantage South-based scholars. COVID's disruptions offer a chance to reorient these collaborations toward more ethical forms of research. We examine the ethical and practical questions inherent in such collaborations and explore two case studies of attempts to reorient collaborative work, drawing primarily on examples of collaboration between African, European, and North American scholars. Cognizant that these efforts are only initial attempts toward reworking collaborative practice, we also trace the challenges they bring, from the duty of care and paternalistic approaches to funding and practical problems. We suggest that a careful consideration of these issues can help to establish more just ways to fully reengage North-South research and collaboration in the wake of the global pandemic.