2016
DOI: 10.1155/2016/8352893
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Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome

Abstract: Importance. Rituximab was not effective in ameliorating the hearing loss in a patient with atypical Cogan's syndrome. Observations. We report the case of a patient who developed acute bilateral uveitis and sensorineural hearing loss. A diagnosis of atypical Cogan's syndrome was made. The patient's hearing loss did not improve despite high dose steroids and azathioprine. Rituximab was administered given a recent report of its efficacy in a patient with refractory disease; however, our patient's hearing loss did… Show more

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Cited by 2 publications
(2 citation statements)
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“…Adanya kondisi gagal respons dalam 2-3 minggu, ketidakmampuan untuk melakukan peningkatan dosis prednisone hingga 10 mg/hari secara bertahap atau terdapat toksisitas yang diinduksi glukokortikoid adalah indikasi penggunaan obat imunosupresif tambahan. 13,14,20 Obat imunosupresif yang telah digunakan termasuk methotrexate (15-25 mg/minggu), azathioprine (1,5-2,5 mg/kg/hari), siklofosfamid (2-3 mg/kg/hari PO), dan siklosporin A (5 mg/kg/hari). Obat-obat ini digunakan apabila terdapat kontra indikasi dalam pemberian kortikosteroid.…”
Section: Laporan Kasusunclassified
“…Adanya kondisi gagal respons dalam 2-3 minggu, ketidakmampuan untuk melakukan peningkatan dosis prednisone hingga 10 mg/hari secara bertahap atau terdapat toksisitas yang diinduksi glukokortikoid adalah indikasi penggunaan obat imunosupresif tambahan. 13,14,20 Obat imunosupresif yang telah digunakan termasuk methotrexate (15-25 mg/minggu), azathioprine (1,5-2,5 mg/kg/hari), siklofosfamid (2-3 mg/kg/hari PO), dan siklosporin A (5 mg/kg/hari). Obat-obat ini digunakan apabila terdapat kontra indikasi dalam pemberian kortikosteroid.…”
Section: Laporan Kasusunclassified
“…Among them, improvement in hearing loss was noted in only one patient [ 48 ]. Lack of efficacy was noted in a patient with atypical CS and non-Hodgkin's lymphoma [ 45 ] and in a patient with steroids and azathioprine-refractory CS [ 49 ].…”
Section: Biological Therapy In Cogan's Syndromementioning
confidence: 99%