2012
DOI: 10.3324/haematol.2011.059246
|View full text |Cite
|
Sign up to set email alerts
|

Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response

Abstract: The online version of this article has a Supplementary Appendix. BackgroundTreatment of follicular lymphoma with rituximab is currently recommended at a dose of 375 mg/m 2 . We aimed to provide a rationale for optimal dosing and scheduling of this anti-CD20 antibody based on pharmacokinetics. Design and MethodsClinical efficacy of immuno-chemotherapy with rituximab, fludarabine and mitoxantrone followed by 2-monthly rituximab maintenance was evaluated in 29 patients with previously untreated follicular lymphom… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

6
80
1
3

Year Published

2012
2012
2021
2021

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 98 publications
(90 citation statements)
references
References 34 publications
6
80
1
3
Order By: Relevance
“…This correlation reached statistical significance at maintenance cycle six. 74 In patients with CLL, an association between drug exposure and clinical response was found: higher values of AUC and C trough were observed in responders than non-responders after 3-6 cycles of drug. 68 In CLL, the higher dose of 500 mg/m 2 allows an AUC at steady-state similar to that achieved with doses of 375 mg/m 2 in patients with B-NHL.…”
Section: Improving Rtx Therapeutic Regimen During Induction and Maintmentioning
confidence: 99%
See 4 more Smart Citations
“…This correlation reached statistical significance at maintenance cycle six. 74 In patients with CLL, an association between drug exposure and clinical response was found: higher values of AUC and C trough were observed in responders than non-responders after 3-6 cycles of drug. 68 In CLL, the higher dose of 500 mg/m 2 allows an AUC at steady-state similar to that achieved with doses of 375 mg/m 2 in patients with B-NHL.…”
Section: Improving Rtx Therapeutic Regimen During Induction and Maintmentioning
confidence: 99%
“…During maintenance therapy, the optimal RTX serum level of 25 μg/ml is achieved when RTX infusions are administered every 2 mo, as indicated by data of Jager, 74 Salles (PRIMA study), 83 Kahl (RESORT study), 84 Berinstein 73 and Gordan.…”
Section: Improving Rtx Therapeutic Regimen During Induction and Maintmentioning
confidence: 99%
See 3 more Smart Citations