Rivaroxaban induced retro peritoneal hematoma: a rare complication of direct oral anticoagulants (DOACs)

Ayoub, Bouaiyda; Chouikh, C.; Ali, Grine; Achraf, Jeddab; Mounir, K.; Balkhi, H.

doi:10.11604/pamj-cm.2020.3.124.24674

Cited by 3 publications

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“…First described by Karl Theodor Fahr in 1930 [ 2 ], Fahr’s disease, also known as striato-pallido-dentate calcifications or idiopathic basal ganglia calcification (IBGC), is a neurodegenerative disease with an autosomal dominant pattern of inheritance [ 3 ] and a single gene locus has been identified on chromosome 14q, although several other studies have identified other genetic mutations, suggesting a heterogenic pattern of inheritance [ 3 ]. One study done by Ding et al identified a new SLC2OA2 mutation of IBGC, which was used to explore the association between different phenotypes and genotypes in Chinese patients with IBGC [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Fahr’s Disease: Case Presentation With Facial Numbness

Shahid,

Dosu,

Nasser

2023

Cureus

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Fahr's disease is a rare hereditary neurological disorder characterized by idiopathic basal ganglia and cerebral cortex calcifications. It presents a wide range of neurological manifestations, including motor dysfunction, sensory deficits, seizures, headaches, visual disturbances, and movement disorders. We present a case report of a 42-year-old female who presented to the accident and emergency department with a stroke alert. Her main symptom was left facial numbness. Otherwise, she was fit and well. A CT scan of her head revealed significant bilateral basal ganglia calcifications rather than ischaemic or haemorrhagic changes. Blood tests showed normal serum calcium, normal phosphate, and normal parathyroid hormone levels. Upon further inquiry, she mentioned that her sister had been diagnosed with similar findings on a brain scan. Subsequently, an MRI scan of her brain was performed, which suggested Fahr's disease. Currently, there is no definitive management available, so a conservative management approach is usually employed based on symptomatology. This case is particularly interesting due to its rarity, strong genetic inheritance, and the development of a management plan.

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Section: Discussionmentioning

confidence: 99%

Fahr’s Disease: Case Presentation With Facial Numbness

Shahid,

Dosu,

Nasser

2023

Cureus

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“…Foram, no entanto, já descritos casos de HRE associados a DOAC. 18,19 Apesar de a maioria dos doentes do nosso estudo ser hipocoagulada, destes, apenas 30% apresentavam um INR ou APTT supra-terapêuticos. De facto, INR supra--terapêutico não está universalmente presente nos casos de HRE.…”

Section: Discussionunclassified

Hematoma Retroperitoneal Espontâneo: A Experiência de um Centro

Beirão

Barreira

Guimarães

2022

Gaz Med

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INTRODUÇÃO: O hematoma retroperitoneal espontâneo (HRE) é uma entidade rara e potencialmente fatal, classicamente descrita como uma complicação da terapêutica anticoagulante. Pode constituir um desafio diagnóstico, dada a heterogeneidade das manifestações clínicas. O objetivo deste estudo é caracterizar uma população de doentes com HRE e identificar fatores preditores de mortalidade.MÉTODOS: Estudo retrospetivo incluindo todos os doentes admitidos num hospital distrital num período de 10 anos (2010-2019) com diagnóstico de HRE. Foram excluídos doentes com história de traumatismo, procedimentos invasivos ou cirurgias nos 14 dias anteriores.RESULTADOS: Foram incluídos 11 doentes; 63,6% eram homens. A idade mediana foi 81 anos. Nove doentes estavam hipocoagulados: 5 com antagonistas da vitamina K, 4 com enoxaparina. O HRE foi o motivo primário de admissão em 45,5% dos casos. Nos restantes, constituiu uma intercorrência de um internamento por outra causa. A apresentaçãoclínica mais comum foi dor abdominal (45,5%), seguida de sintomas de baixo débito (36,4%). Três doentes apresentavam um INR supraterapêutico. Todos os doentes foram tratados de forma conservadora. A mortalidade global aos 30 dias foi 36,4%; a mortalidade intra-hospitalar foi 54,5%. O HRE foi considerado a causa direta da morte em apenas 18,2%. O único fator que se associou a maior mortalidade foi o agravamento da função renal (p=0,029).CONCLUSÃO: O HRE ocorre sobretudo em doentes idosos e hipocoagulados. Associa-se a elevada mortalidade, mas tipicamente não é a causa direta da morte. É difícil identificar fatores preditores de mortalidade, parecendo, contudo, que o agravamento da função renal se associa a maior risco.

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First-time seizure revealing late-onset Fahr’s disease: a case report and brief literature review

Lamessa,

Tesfaye,

Woyimo

et al. 2024

Front. Hum. Neurosci.

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Fahr’s disease (FD), otherwise known as primary familial brain calcification, is a rare neurodegenerative condition that involves intracerebral calcification at the level of the basal ganglia and other brain regions. It is an inherited neurologic disorder, although its molecular genetics have not been thoroughly defined. Patients usually present with a wide range of symptoms, predominantly movement disorders and cognitive changes. However, seizures are a rare initial presenting features of late-onset FD in adults. Herein, we present the case of a 60-year-old man with no known chronic illnesses who was admitted to a tertiary hospital after experiencing first-time generalized tonic-clonic seizures and loss of consciousness for two days. Basic laboratory results were within normal limits, and a non-contrast brain computed tomography (CT) scan showed intracerebral calcification. The patient was diagnosed with epilepsy secondary to FD based on its modified diagnostic criteria and responded well to antiepileptic treatment. The case highlights a rare association and emphasizes the importance of considering this diagnosis in patients experiencing an inaugural seizure; appropriate tests should be performed to confirm or rule out other relevant and secondary causes, and the treatment should be modified accordingly.

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Rivaroxaban induced retro peritoneal hematoma: a rare complication of direct oral anticoagulants (DOACs)

Cited by 3 publications

References 0 publications

Fahr’s Disease: Case Presentation With Facial Numbness

Fahr’s Disease: Case Presentation With Facial Numbness

Hematoma Retroperitoneal Espontâneo: A Experiência de um Centro

First-time seizure revealing late-onset Fahr’s disease: a case report and brief literature review

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