The purpose of this research is to present a model of highland vegetable farming based on local wisdom. The research was conducted purposively on the Upper Serayu River Basin covering two districts, namely Banjarnegara and Wonosobo. The quantitative and qualitative data were analyzed descriptively. The results indicate that the farmers play important roles based on the local wisdom, including returning plant residues into the soil (recycling), using organic fertilizers, implementing crop rotations, implementing optimum water management, using specific environmental varieties, conducting pest and disease control with IPM principles, using anorganic fertilizers, making terraces on slopes, and planting avocation resistant crops. The model of highland vegetable farming based on local wisdom is influenced by uncontrollable and controlled factors, such as macro climate condition (rainfall) and socio-economic of farmers as well as farm management. The model will generate desired outputs and undesired outputs; both outputs affect the local advantages. Keywords: model of highland vegetable farming, local wisdom, uncontroled and controled factors, desired and undesired output..