The Amazon River system developed into its present form in a comparatively short period over approximately the last 10 million years. The western part of the drainage basin was mainly controlled by exhumation of the Andes. The Cenozoic Andean foreland consisted of a series of subsiding aggradational basins, interrupted by segments of basement (arches), which were particularly active during the Neogene. In this geodynamic landscape a system of highly instable rivers developed. During the Quaternary, landscape evolution was controlled by glacio-eustatic changes. The central to eastern part of the basin (i.e. the lower reaches of the AmazonSolimões River) was most affected by glacio-eustacy and the effect extended upstream beyond the halfway point of the continent. The present várzeas and the numerous associated ria lakes are an indication of incomplete infi lling of the palaeovalleys that were incised during the low-sea-level periods. In the Andean forelands, the soils in terra fi rme are highly variable due to their different sedimentation histories, parent materials and drainage conditions. The heterogeneity of the edaphic site properties infl uences the distribution patterns of the Amazonian biota, with highly specialized habitats occurring in the most extreme conditions. Denudation with deep alteration of the former aggradational plains in western Amazonia modifi es the forest ground with time; also in the Precambrian shields in northern and southern parts of Amazonia, forest soils have been altered by deep weathering under the hot and moist tropical climatic conditions of the region. In this chapter we describe in particular the evolution of the fl uvial landscapes in the Amazon drainage basin from the Miocene onwards, with particular emphasis on the Quaternary.