River therapy

Roviello, Valentina; Gilhen-Baker, Melinda; Roviello, Giovanni N.; Lichtfouse, Éric

doi:10.1007/s10311-021-01373-x

Cited by 16 publications

(14 citation statements)

References 42 publications

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“…Similarly, topical use of apiin and hyperoside, after prolonged and repeated exposure to river waters or after their concentration (or extraction from plants) considering the ≤5 µg/L concentration could also work directly on the inflammatory region to improve the symptoms of psoriasis, avoiding adverse systemic effects thanks to the topical administration route [ 34 ]. Overall, the in silico findings described in this work, alongside the importance of protecting from pollution the riverine habitats [ 35 , 36 , 37 , 38 , 39 ] that are particularly rich in forests, living organisms in turn endowed with enormous benefits for human life [ 40 , 41 , 42 , 43 , 44 , 45 ], all concur to highlight the role that pristine rivers have on health and wellbeing of individuals.…”

Section: Resultssupporting

confidence: 54%

The Healing Power of Clean Rivers: In Silico Evaluation of the Antipsoriatic Potential of Apiin and Hyperoside Plant Metabolites Contained in River Waters

Roviello

Gilhen-Baker²,

Vicidomini

et al. 2022

IJERPH

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Humanity may benefit greatly from intact riverine ecosystems not only because they supply water to be used in the most common human activities, but also for the effects that clean rivers can have on human health. Herein, we used a computational approach to show that some phytochemicals produced by riparian plants as secondary metabolites, which are naturally released into river waters, can have therapeutic properties. These include antipsoriatic activities which we demonstrated in silico by modelling the interaction of apiin, guanosine and hyperoside, a few main river plant metabolites, with NF-kB, IL-17 and IL-36, which are recognized targets involved in psoriasis disease. In particular, we found that apiin and hyperoside are endowed with docking energies and binding affinities which are more favorable than the known reference inhibitors of the three protein targets whilst, in silico, guanosine shows comparable activity with respect to the inhibitors of IL-36 and NF-kB. The low skin permeation (logKp < −8) we predicted for apiin and hyperoside led us to hypothesize their possible utilization as topic antipsoriatic therapeutics, and in particular after PAINS (pan-assay interference compounds) score evaluation, we reached the conclusion that apiin, with no predicted tendency to react nonspecifically with the numerous targets involved in the biological cellular pathways, is particularly interesting for the desired therapeutic application.

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Section: Resultssupporting

confidence: 54%

The Healing Power of Clean Rivers: In Silico Evaluation of the Antipsoriatic Potential of Apiin and Hyperoside Plant Metabolites Contained in River Waters

Roviello

Gilhen-Baker²,

Vicidomini

et al. 2022

IJERPH

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“…While these studies have not directly addressed COVID-19, the benefits of exercise for COVID-19 have already been discussed at length, and reductions in stress are likely to directly improve immune function. Roviello et al [212] further suggest that swimming in or walking along (clean) rivers may be directly beneficial in a similar way to forest bathing, given the occurrence of many secondary plant metabolites in rivers. In addition to the already known benefits of rivers, such as sights and sounds, and gentle exercise, the compounds from riparian vegetation may act in a similar way to the forest phytoncides [212] .…”

Section: Time In Naturementioning

confidence: 99%

“…Roviello et al [212] further suggest that swimming in or walking along (clean) rivers may be directly beneficial in a similar way to forest bathing, given the occurrence of many secondary plant metabolites in rivers. In addition to the already known benefits of rivers, such as sights and sounds, and gentle exercise, the compounds from riparian vegetation may act in a similar way to the forest phytoncides [212] . More broadly, interaction with nature of all types, from walking in the mountains to watching wildlife in grass meadows, has been suggested to improve health outcomes through a myriad of mechanisms: these are discussed at length by Kuo [213] .…”

Section: Time In Naturementioning

confidence: 99%

COVID-19: Reducing the risk via diet and lifestyle

Campbell¹

2023

Journal of Integrative Medicine

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“…These defenses can be classified into two types: innate immunity and adaptive immunity, in which particular immune components work together to counteract infections. In addition to genetic factors that have an effect on human immune function, aging, lifestyle choices [ 1 ], and environmental determinants [ 2 , 3 ] can also affect our susceptibility to disease-causing agents. It has been established that certain foods contain chemical components that may regulate signal transduction, cell phenotypes, and pathophysiology [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Protective Effect of Food Drugs against Viral Diseases: Interaction of Functional Food Ingredients and SARS-CoV-2, Influenza Virus, and HSV

Ricci¹,

Roviello²

2023

Life

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A complex network of processes inside the human immune system provides resistance against a wide range of pathologies. These defenses form an innate and adaptive immunity, in which certain immune components work together to counteract infections. In addition to inherited variables, the susceptibility to diseases may be influenced by factors such as lifestyle choices and aging, as well as environmental determinants. It has been shown that certain dietary chemical components regulate signal transduction and cell morphologies which, in turn, have consequences on pathophysiology. The consumption of some functional foods may increase immune cell activity, defending us against a number of diseases, including those caused by viruses. Here, we investigate a range of functional foods, often marketed as immune system boosters, in an attempt to find indications of their potential protective role against diseases caused by viruses, such as the influenza viruses (A and B), herpes simplex virus (HSV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in some cases mediated by gut microbiota. We also discuss the molecular mechanisms that govern the protective effects of some functional foods and their molecular constituents. The main message of this review is that discovering foods that are able to strengthen the immune system can be a winning weapon against viral diseases. In addition, understanding how the dietary components function can aid in the development of novel strategies for maintaining human bodily health and keeping our immune systems strong.

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River therapy

Cited by 16 publications

References 42 publications

The Healing Power of Clean Rivers: In Silico Evaluation of the Antipsoriatic Potential of Apiin and Hyperoside Plant Metabolites Contained in River Waters

The Healing Power of Clean Rivers: In Silico Evaluation of the Antipsoriatic Potential of Apiin and Hyperoside Plant Metabolites Contained in River Waters

COVID-19: Reducing the risk via diet and lifestyle

Exploring the Protective Effect of Food Drugs against Viral Diseases: Interaction of Functional Food Ingredients and SARS-CoV-2, Influenza Virus, and HSV

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