The need for safe and good quality drinking water is growing rapidly worldwide, especially with increased urbanization and population growth. However, increasing pollution of surface waters, often by wastewater effluents, has made water treatment more difficult and expensive. Furthermore, most water resources, especially surface waters in industrialized and urban areas in developing countries, are quickly deteriorating as a result of uncontrolled waste discharges into receiving waters, which may also serve as drinking water sources. Consequently, this has led to the occurrence of potentially harmful organic micropollutants (OMPs) in drinking water treatment systems and ultimately in drinking water.This study has been carried out within the framework of the European research project SWITCH (Sustainable Urban Water Management Improves Tomorrow's City's Health). SWITCH is supported by the European Commission under the 6th Framework Programme and contributes to the thematic priority area of "Global Change and Ecosystems" [1.1.6.3] Contract n° 018530-2. This study also partly supported by K-Water, UNESCO fellowship and Halla Energy and Environment. I would like to thank following MSc students for their supports (Mohammed Ibrahim, Emmanuel Ameda, Sharada Devkota, Henny Simarmata and Chol Abel). I want to express my great gratitude to Aleksandra Magic-Knezev, who helped me for allowing the use of advanced facilities in HetWaterlaboratorium. I would like to acknowledge the help of Theo van der Kaaij and Ineke van der Veer-Agterberg (HetWaterlaboratorium) for the support on LC-OCD/OND and ATP measurements. I want to express my gratitude to Dr. Gesche Grützmacher for advices and suggestions and the data from KWB Berlin. I want to thank Dr. Frank Sacher for analytical support for measuring pharmaceutically active compounds. I want to thank Karin Lekkerkerker for the support on translating samenvatting and proposition.The members of UWS and laboratory staff in UNESCO-IHE have been a marvellous source of advices, supports, and ideas. Thanks go to Tanny van der Klis, Fred Kruis, Don van Galen, Peter Heerings, Lyzette Robbmont, Frank Widgman and Jolanda Boots. Special thanks should also go to the friends that maintained my sanity throughout Ph.