Riwayat Pengobatan dan Komorbid Diabetes Mellitus Berhubungan Dengan Kejadian Tuberkulosis Resisten Obat

Abstract

Tujuan penelitian untuk menganalisis hubungan antara riwayat pengobatan Tuberkulosis (TB) sebelumnya dan komorbid Diabetes Mellitus (DM) dengan kejadian Tuberkulosis Resisten Obat (TB RO) di Kabupaten Poso. Metode penelitian yaitu observasional analitik dengan desain studi case control. Populasi yaitu seluruh pasien penderita TB di Kabupaten Poso. Sampel yaitu 32 pasien TB RO sebagai kelompok kasus dan 32 penderita TB Sensitifi Obat (TB SO) sebagai kelompok kontrol. Pengambilan data dengan mengidentifikasi data Sistem Informasi Tuberkulosis (SITB). Analisis statistik menggunakan uji chi Square. Hasil penelitian menunjukkan pasien TB yang pernah menjalani pengobatan sebelumnya yaitu TB RO sebesar 65,5% dan TB SO sebesar 18,8%, dengan nilai p = 0,000, pasien TB yang tidak teratur minum obat yaitu TB RO sebesar 71,9% dan TB SO sebesar 15,6% dengan nilai p = 0,000, pasien TB yang menderita komorbid DM yaitu TB RO sebesar 31,3% dan TB SO sebesar 6,3% dengan nilai p = 0,025. Kesimpulan terdapat hubungan antara riwayat pengobatan sebelumnya dan adanya komorbid DM dengan kejadian TB RO pada pasien TB di Kabupaten Poso. Saran agar fasilitas pelayanan kesehatan meningkatkan manajemen program layanan TB untuk menjamin keteraturan minum obat sehingga mencegah terjadinya TB RO.

Risk Characterization of Treatment Histories and Comorbidities Regarding Tuberculosis Treatment Status in West Sumatra Province 2020-2021

“…If the air containing TB bacteria is inhaled, there is a chance that those nearby will contract tuberculosis; if the immune system is compromised, transmission will be facilitated. In addition, this study is consistent with research conducted by Manggasa 2022 (12) regarding the History of Treatment and Comorbid Diabetes Mellitus Associated with the Incidence of Drug-Resistant Tuberculosis, which states that TB disease can be contracted even if there is no history of prior treatment.…”

“…This research is consistent with the findings of manggasa 2020 (12) and Lilia Damayanti 2022 (2), who discovered that the majority of TB patients who did not have a history of drug failure were new TB patients. This contradicts the results of a study conducted by Nurmala 2020 (15) in Kupang, which found that more TB patients had failed treatment.…”

“…In this study it was found that there were 130 (81%) cases of TB RO, most of them had no known history of diabetes mellitus (dm), namely by distribution, compared to tuberculosis patients with a known history of diabetes mellitus (dm) 31 (19.2%), whereas of the 161 cases of tuberculosis, most also had no known history of diabetes mellitus (dm), namely with a frequency distribution of 108 (67%) than TB patients with known history of diabetes mellitus (DM). This is consistent with the findings of Manggasa 2022 (12) and Nurwanti 2016 ( 16), who discovered that the majority of respondents had a diabetes history that was unknown both before and during treatment because many refused to be examined or have their blood extracted.…”

“…Based on the OR value of 16.4, it was determined that not having a history of drug failure increased the risk of TB treatment status by 16.4 times.The findings of this investigation are consistent with previous research. This research is also consistent with the research conducted by Manggasa 2022(12) and regarding the History of Treatment and Comorbid Diabetes Mellitus Associated with the Incidence of Drug-Resistant Tuberculosis, which states that a person has contracted TB disease despite having no prior treatment history. Possibilities include a history of intimate contact with TB-related organisms and TB patients, as well as dishonesty on the part of TB patients in providing information regarding previous treatment(12).…”

“…According to research conducted by Lilia Damayanti in 2022 (2), 32 out of 48 respondents were newly diagnosed TB patients. In addition, according to a study conducted by Manggasa (2022), 81.2% of TB SO patients were newly diagnosed TB patients.…”