Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy

Abstract

In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.

Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid

“…New Zealand rabbit (1.8–2.5 kg) was purchased from the Chengdu Dashuo Experimental Animal (Chengdu, China), and were kept under constant conditions (temperature 25 ± 1 °C). Rabbits were randomly divided into four groups: normal keloid group (Control), Gla group, Blank-MN group and Gla-MN group ( n = 5) ( Hong et al, 2018 ; Zhong et al, 2024 ). Briefly, rabbits were anesthetized by intravenous injection of pentobarbital sodium (30 mg/kg, iv.…”

“…In vitro transdermal study of mouse skin was carried out using Franz diffusion cell ( Sabbagh et al, 2023 ; Zhong et al, 2024 ). Briefly, Gla-MN was inserted into the skin without subcutaneous fat, and the skin was fixed and dipped into a diffusion tank ( Ronnander et al, 2018 ).…”