Rizatriptan

Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity

“…Several organs such as liver are involved in triptans adverse effects. [15][16][17] It is well known that imbalance between antioxidant defense and ROS generation (e.g., glutathione) to removal of ROS lead to oxidative stress. 49 GSH is an important antioxidant defense molecule for removal of reactive oxygen species such as lipid hydroperoxides and H 2 O 2 .…”

“…16 Another case report was a 17-year-old girl who developed hepatotoxicity during treatment with antimigraine triptans. 17 Sumatriptan is in the possible hepatotoxic class of drugs according to its structural moiety. 18 In vitro studies performed in tube in absence of cells, suggested that sumatriptan has direct scavenging activity on free radicals, 19 but this medication have several metabolites after enzymatic processes in the body, thus, the overall outcome should be clarified.…”