Best-effort service model of traditional routing is gradually hard to meet the personalized demands under the rapid development of network technologies (e.g. 5G and IPv6). Therefore, service customization should be considered. In this work, a service customized routing mechanism based on deep learning in IPv6 network is proposed, which includes deep learning-based service customization module, reliability evaluation module, and routing calculation module. The first module uses neural network to learn the complex service customization function, which can quickly output win-win customized service strategies based on user demands. The second module can quantify the reliability of service routing paths, where not only the link status of IPv6 Neighbor Unreachable Detection (NUD) is considered, but also propose link performance weights to ensure the reliability of differentiated service performance. The third module uses the gray wolf optimization algorithm to calculate an optimal routing path to forward services with the customized strategies as the constraints and the maximum reliability and minimum cost as the goal. Finally, the mechanism is tested on the IPv6 Source Address Validation Improvement (SAVI) platform, which can reduce the execution time by 12.25% and improve the average routing reliability, user and ISP satisfaction by 9.0%, 40.45% and 7.4%, respectively.