RM and log P values of 5-nitroimidazoles

Determination of Hydrophobicity Parameters of Antibiotics by Reversed-Phase Chromatography. The Effect of Support

“…However, the use of RP-TLC has some disadvantages too. The support can partially retain its original adsorption character even after impregnation (Guerra et al, 1981;Giesen and Janssen, 1982), and the surface pH of the support may influence the retention of polar compounds Cserhiti, 1988, 1989).…”

On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole

“…1 has one ionizable group ( N 3 of the imidazole ring) with a p K a value of 1.82,17 and therefore,18 its first‐order hydrolysis rate constant is described by where M 1 – M 4 are the so‐called macro constants, each combining kinetically indistinguishable reaction rate constants: …”

Review of Research on Quantitative Structure-Retention Relationships in Thin-Layer Chromatography

“…This will make QSRR equations have general meaning. Downloaded by [University of California, San Francisco] at 00:07 31 August 2014 10 WANG AND ZHANG From the viewpoint of application, QSRR equations in TLC are mainly used for retention prediction. Explanation of separation mechanisms remains for further investigation.…”

“…This linear relationship has been verified in many studies. 8,9 Biagi et al 10 (n is the number of compounds being studied; r is the correlation coefficient; s is standard deviation; F is the overall F-test for the regression; p is the level of significance). ΣMR 1-2 is the molar refractivity summed over the R 1 and R 2 groups.…”

“…Biagi et al 10 found that there is a quadratic relationship between R m values and log 1/C for xanthone: …”