RNA-binding Motif Protein 45 (Rbm45)/Developmentally Regulated RNA-binding Protein-1 (Drbp1): Association with Neurodegenerative Disorders

Abstract

Neurodegenerative disorders are caused by the progressive loss of the structure and/or function of neurons, often through cell death, contributing significantly to morbidity and mortality. Cytoplasmic aggregation of proteins into inclusion bodies is a pathological characteristic of amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disorder (AD). These inclusion bodies have been shown to contain RNA-binding proteins participating in RNA-dependent and RNA–independent protein:protein interactions. RNA-binding motif protein 45 (RBM45), also known as developmentally regulated RNA-binding protein-1 (Drbp1), was first identified as a novel RNA binding protein in rat that functions in neural development. Advancing research has indicated a connection between the presence of human RBM45 protein cytosolic aggregates and degenerative neurological diseases. This review considers the structure, function, and distribution of RBM45 along with a look into potential future research on this multifunctional RNA-binding protein.

Genome-Wide Gene-Based Multi-Trait Analysis

“…For the 12 genes associated with multi-trait of brain atrophy in AD patients, some of them have been reported in the literature. For example, gene RBM45, known as the RNAbinding motif protein 45 or developmentally regulated RNAbinding protein-1 (Drbp1), has been shown to be associated with the degenerative neurological changes in AD patients (Eck et al, 2018). Gene UPK1B has been shown to be cooperated with CD9 and CD81 and is directly involved in the pathological process of AD (De Strooper and Wakabayashi, 2011;Orre et al, 2014;Wężyk and Żekanowski, 2017).…”

Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa

“…Specifically, RNA recognition motif-type (RRM) binding domain proteins (RBDPs) have been demonstrated to regulate post-transcriptional RNA metabolism by modulating the longevity [2][3][4][5] and translational efficacy [6][7][8][9][10][11] of target mRNAs and contributing to splicing reactions [12]. RBDPs have also been identified participating in RNA-mediated [13][14][15][16][17][18] and RNA-independent protein-protein complexes [19][20][21]. These biochemical properties of RBDPs have been linked to roles in apoptosis [22], tumorigenesis [23], and neuropathology [24,25].…”

Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa

“…Specifically, RNA recognition motif-type (RRM) binding domain proteins (RBDPs) have been demonstrated to regulate post-transcriptional RNA metabolism by modulating the longevity [2][3][4][5] and translational efficacy [6][7][8][9][10][11] of target mRNAs and contributing to splicing reactions [12]. RBDPs have also been identified participating in RNA-mediated [13][14][15][16][17][18] and RNA-independent proteinprotein complexes [19][20][21]. These biochemical properties of RBDPs have been linked to roles in apoptosis [22], tumorigenesis [23], and neuropathology [24,25].…”