RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer

Long Non-Coding RNA Generated fromCDKN1AGene by Alternative Polyadenylation Regulates p21 Expression during DNA Damage Response

“…Interestingly, HuR depletion upon UV treatment (Supplementary Figure S2D) abolished not only the previously described increase in CDKN1A full-length mRNA (35) but also induction of both unspliced SPUD and SPUD (Figure 4F, Supplementary Figure S2E). As HuR is a highly abundant nuclear protein (63), overexpression of HuR did not affect the UV-induced increase in CDKN1A full-length mRNA, unspliced SPUD and SPUD (Supplementary Figure S2F).…”

RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5ʹ-untranslated region

“…Though our results suggest RBM24 as an anti-SARS-CoV-2 target, the detail mechanism of RBM24 in virus replication needs more deep investigation. RBM24 was supposed to be a potential therapeutic target for cancer treatment ( Shi, 2022 ), And different efforts such as small molecule inhibitors, siRNA, peptides and CRISPR-based therapies had been made to target RBP functions for cancer therapy ( Mehta et al, 2022 ). However, how to deliver the drugs to specific tissues with minimal cytotoxicity to normal cells is the main question, which is the same for the antivirus purpose.…”

Tackling the HuRdle of radioresistance: a radiation perspective on the RNA-binding protein HuR

“…Molecular mechanisms have been investigated to a substantial degree, mainly focusing on ties between HuR expression and stress response as well as DNA damage repair. DNA damage may induce cytosolic translocation of HuR via activation of the damage proteins checkpoint kinase 1 (CHK1) and p38 mitogen-activated protein kinase (p38 MAPK) ( 19 , 20 ). HuR may then further increase DNA damage protein translation ( 19 ).…”