RNA Interference: A New Hope in Understanding and Treatment of Psychiatric Disorders

Kocak, Emine Eren

doi:10.5455/bcp.20120731055453

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Recently, it was reported that chronic stress in a murine model was targeting an RNASE II enzyme complex (DROSHA subunit) via differential hypomethylation at that locus. A decrease in methylation suggests there is a concomitant increase in the non-specific expression of the target gene, and in this case, it would mean an increase in RNAi-mediated epigenetic ablation of gene expression [5].…”

Section: Diaeventological Sources Of Gadmentioning

confidence: 99%

The Diaeventology of Anxiety Disorders

Guerra¹

2019

Anxiety Disorders - From Childhood to Adulthood

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Anxiety is a crippling neuropsychiatric condition that encompasses a complex endophenotypic network of genetic, immunological, epigenetic, and metabolic mechanisms, interacting with the environment. A new approach to complex biological systems, including mental states and their neurological correlates, is diaeventology, a paradigm that exposes the event ontologies of these biomolecular/cellular mechanisms. General anxiety disorder has been studied in subclinical and clinical research settings where evidence is obtained for a longitudinal patterning of chronic and episodic and often increasingly stressful life events that provide the etiology and development of the pathology. Early events that involve brain oxygen deprivation coupled with carbon dioxide abundance are linked to biochemical and epigenetic processes associated with anxiety instantiation. A verified analysis of the current evidence suggests a neuroimmune mechanism that aligns with stress pathophysiology and epigenetic re-tailoring of key genomic loci that inappropriately compensate and misdirect biological defense mechanisms toward central nervous system dysfunction presenting as anxiety disorders.

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Section: Diaeventological Sources Of Gadmentioning

confidence: 99%