2024
DOI: 10.1017/neu.2024.36
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RNA m6A methyltransferase activator affects anxiety-related behaviours, monoamines and striatal gene expression in the rat

Margus Kanarik,
Kristi Liiver,
Marianna Norden
et al.

Abstract: Modification of mRNA by methylation is involved in post-transcriptional regulation of gene expression by affecting the splicing, transport, stability and translation of mRNA. Methylation of adenosine at N6 (m6A) is one of the most common and important cellular modification occurring in the mRNA of eukaryotes. Evidence that m6A mRNA methylation is involved in regulation of stress response and that its dysregulation may contribute to the pathogenesis of neuropsychiatric disorders is accumulating. We have examined… Show more

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