RNA methylation, homologous recombination repair and therapeutic resistance

Bai, Yu; Zhao, Hanlin; Liu, Haijun; Wang, Wei; Dong, Hongming; Zhao, Chenghai

doi:10.1016/j.biopha.2023.115409

Biomedicine & Pharmacotherapy

2023

DOI: 10.1016/j.biopha.2023.115409

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RNA methylation, homologous recombination repair and therapeutic resistance

Yu Bai,

Hanlin Zhao,

Haijun Liu

et al.

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2024

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Cited by 2 publications

References 176 publications

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Crosstalk of methylation and tamoxifen in breast cancer (Review)

Shen,

He,

et al. 2024

Mol Med Rep

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Tamoxifen is a widely used anti-estrogen drug in the endocrine therapy of breast cancer (BC). It blocks estrogen signaling by competitively binding to estrogen receptor α (ERα), thereby inhibiting the growth of BC cells. However, with the long-term application of tamoxifen, a subset of patients with BC have shown resistance to tamoxifen, which leads to low overall survival and progression-free survival. The molecular mechanism of resistance is mainly due to downregulation of ERα expression and abnormal activation of the PI3K/AKT/mTOR signaling pathway. Moreover, the downregulation of targeted gene expression mediated by DNA methylation is an important regulatory mode to control protein expression. In the present review, methylation and tamoxifen are briefly introduced, followed by a focus on the effect of methylation on tamoxifen resistance and sensitivity. Finally, the clinical application of methylation for tamoxifen is described, including its use as a prognostic indicator. Finally, it is hypothesized that when methylation is used in combination with tamoxifen, it could recover the resistance of tamoxifen.

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Crosstalk of methylation and tamoxifen in breast cancer (Review)

Shen,

He,

et al. 2024

Mol Med Rep

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The Investigation into Intrinsic Elements Influencing the Onset of Lung Cancer

Chen,

Lin,

2024

JBM

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Lung cancer is a highly heterogeneous malignancy with a complex pathogenesis, involving a series of endogenous alterations such as genetic mutations, epigenetic modifications, and oxidative stress. Recent advancements in lung cancer research, especially at the genomic and molecular biology levels, have continuously provided new potential targets and perspectives for the diagnosis and treatment of lung cancer. Therefore, this article summarizes the recent progress in the study of endogenous factors related to the pathogenesis of lung cancer, aiming to enhance the understanding of intrinsic factors in lung cancer and to organize ideas for subsequent related research.

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RNA methylation, homologous recombination repair and therapeutic resistance

Cited by 2 publications

References 176 publications

Crosstalk of methylation and tamoxifen in breast cancer (Review)

Crosstalk of methylation and tamoxifen in breast cancer (Review)

The Investigation into Intrinsic Elements Influencing the Onset of Lung Cancer

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