RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer

Luo, Yongzhou; Tian, Wenwen; Kang, Da; Wu, Linyu; Tang, Hailin; Wang, Sifen; Zhang, Chao; Xie, Yi; Zhang, Yue; Xie, Jindong; Deng, Xinpei; Zou, Hao; Wu, Hao; Lin, Huan; Wei, Weidong

doi:10.1016/j.jare.2024.06.029

Journal of Advanced Research

2024

DOI: 10.1016/j.jare.2024.06.029

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RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer

Yongzhou Luo,

Wenwen Tian,

Da Kang

et al.

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2024

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Cited by 3 publications

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The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

Li,

Zeng,

Liu

et al. 2024

Clinical & Translational Med

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BackgroundThe modification of N6‐methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptive immune systems through various pathways, including the regulation of messenger RNA. The YTH domain protein family, acting as “readers” of m6A modifications, affects RNA splicing, stability, and immunogenicity, thereby playing essential roles in immune regulation and antitumor immunity. Despite their significance, the impact of the YTH domain protein family on tumor initiation and progression, as well as their involvement in tumor immune regulation and therapy, remains underexplored and lacks comprehensive review.ConclusionThis review introduces the molecular characteristics of the YTH domain protein family and their physiological and pathological roles in biological behavior, emphasizing their mechanisms in regulating immune responses and antitumor immunity. Additionally, the review discusses the roles of the YTH domain protein family in immune‐related diseases and tumor resistance, highlighting that abnormal expression or dysfunction of YTH proteins is closely linked to tumor resistance.Key points This review provides an in‐depth understanding of the YTH domain protein family in immune regulation and antitumor immunity, suggesting new strategies and directions for immunotherapy of related diseases. These insights not only deepen our comprehension of m6A modifications and YTH protein functions but also pave the way for future research and clinical applications.

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The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

Li,

Zeng,

Liu

et al. 2024

Clinical & Translational Med

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RNA methylation and breast cancer: insights into m6A, m7G and m5C

Dai,

Zhao,

Chen

et al. 2024

Mol Biol Rep

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Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer

Sun,

Zhang,

Cao

et al. 2024

Journal of Advanced Research

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RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer

Cited by 3 publications

References 73 publications

The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

The YTH domain‐containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets

RNA methylation and breast cancer: insights into m6A, m7G and m5C

Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer

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