RNA modifications in hematological malignancies

Ferroptosis contributes to the progression of female-specific neoplasms, from breast cancer to gynecological malignancies in a manner regulated by non-coding RNAs: Mechanistic implications

“…Mechanistically, circ_0008035 underexpression results in the suppression of gastric cancer cell proliferation, which in turn causes an increase in apoptosis, as well as ferroptosis. Li et al suggest that the inhibition of ferroptosis in gastric cancer is due to direct targeting of MIR5 99 by overexpressed circ_0008035 through the MIR599 -EIF4A1 (eukaryotic translation initiation factor 4A1) regulatory axis [ 147 ].…”

Nanopore-based native RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between RNA regulatory features

“…RNA methylation has been shown to influence many steps in an mRNA life cycle, particularly RNA processing and splicing, RNA stability and translation 9 . Unlike meRIP or miCLIP which only 7 distinguish between m 6 A and non-m 6 A marked RNA molecules, dRNA-sequencing analysis enables the stoichiometric assessment of m 6 A decorated nucleobases.…”

“…m 6 A sites are recognized and interpreted by "reader" proteins including YT521-B homology (YTH) family of reader proteins (YTHDC1/2 and YTHDF1/2/3) 3 . RNA methylation plays a key role in modulating many critical physiological processes such as control of stem cell function and differentiation 4,5 , immunity 6,7 and cancer development 8,9 . These highlight the importance of precise identification and characterization of RNA modifications in the context of their interaction with various RNA features to influence the fate of an mRNA during its life cycle.…”