“…Tau aggregation on the other hand has been reported to be stimulated by RNA (Kampers et al, 1996;Zhang et al, 2017), while the aggregation of Aβ has been reported to be inhibited (Mathura et al, 2005;Takahashi et al, 2009), a finding also confirmed here. Thus, it is clear that polyanions, at least in vitro, have diverse and sometimes paradoxical effects on protein structure and solubility, possibly depending on the protein / polyanion concentration (Kovachev et al, 2017;Kovachev et al, 2019;Maharana et al, 2018).…”