RNA Polymerases and Transcription Factors

Tyler, Brett M.; Holland, Michael J.

doi:10.1007/978-3-662-10367-8_5

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Cited by 2 publications

(2 citation statements)

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“…RNA polymerase I and RNA polymerase II share several common subunits and TBP is a component of key transcription factors in each case (reviewed by Tyler and Holland, 1996). Therefore, a common regulatory protein is plausible.…”

mentioning

confidence: 99%

Carbon Regulation of Ribosomal Genes in Neurospora crassa Occurs by a Mechanism Which Does Not Require Cre-1, the Homologue of the Aspergillus Carbon Catabolite Repressor, CreA

Serna

Tyler

1999

Fungal Genetics and Biology

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mentioning

confidence: 99%

Carbon Regulation of Ribosomal Genes in Neurospora crassa Occurs by a Mechanism Which Does Not Require Cre-1, the Homologue of the Aspergillus Carbon Catabolite Repressor, CreA

Serna

Tyler

1999

Fungal Genetics and Biology

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“…The genes encoding the large rRNAs are transcribed by RNA polymerase I, while the 5S rRNA genes are transcribed by RNA polymerase III and r-protein genes by RNA polymerase II. The common features of these transcriptional systems are shared subunits of the RNA polymerases and the involvement of the TATA binding protein (TBP) (reviewed by Tyler and Holland 1996).…”

Section: Introductionmentioning

confidence: 99%

Non-coordinate regulation of 5S rRNA genes and the gene encoding the 5S rRNA-binding ribosomal protein homolog in Neurospora crassa

Serna

Cujec²,

Shi³

et al. 2000

Mol Gen Genet

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In eukaryotes, the levels of ribosomal proteins are coordinately regulated under varying nutritional conditions and at different developmental stages. Little is known about how ribosomal protein levels are coupled to the levels of rRNA. The formation of a ribonucleoprotein particle composed of 5S rRNA and a ribosomal protein is an early step in ribosome assembly. To investigate how these two ribosomal components are regulated in Neurospora crassa, we cloned the gene encoding the 5S rRNA-binding ribosomal protein (crp-4) and developed a novel system for measuring relative 5S rRNA transcriptional rates in vivo, using a reporter RNA derived from the 40S precursor RNA. The reporter RNA is cleaved from the 5S rRNA in vivo and therefore allows us to distinguish between changes in the 5S rRNA transcription rate and 5S rRNA stability. Using this system, we found that transcription of 5S rRNA is constitutive and is not coordinated with the levels of crp-4 mRNA or with 40S rRNA levels during a carbon upshift or a carbon downshift.

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RNA Polymerases and Transcription Factors

Cited by 2 publications

References 258 publications

Carbon Regulation of Ribosomal Genes in Neurospora crassa Occurs by a Mechanism Which Does Not Require Cre-1, the Homologue of the Aspergillus Carbon Catabolite Repressor, CreA

Carbon Regulation of Ribosomal Genes in Neurospora crassa Occurs by a Mechanism Which Does Not Require Cre-1, the Homologue of the Aspergillus Carbon Catabolite Repressor, CreA

Non-coordinate regulation of 5S rRNA genes and the gene encoding the 5S rRNA-binding ribosomal protein homolog in Neurospora crassa

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