2022
DOI: 10.26434/chemrxiv-2022-zwh2t-v2
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RNA polymerisation without catalyst from 2’,3’-cyclic nucleotides by drying at air-water interfaces

Abstract: For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step. We found alkaline, uncatalysed drying conditions in bulk and at heated air-water interfaces where 2´,3´-cyclic nucleotides polymerised, forming up to 10-mers within a day. The polymerisation proceeded at a pH range of 7-12 at temperatures between 40-80 °C and was marginally enhanced by K+ ions. Among the canonical ribonucleotides, cGMP polymerised most efficiently. Quantification was performed using HPLC coupled to ESI… Show more

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