RNA-Seq Analysis of Activated PBMC Treated With LMWF5A Predicts an Anti-Inflammatory Mode of Action and Similar Drug Targets to Dexamethasone

Frederick, Elizabeth; Hausburg, Melissa; Thomas, Gregory W.; Bar‐Or, David

doi:10.21203/rs.3.rs-790987/v2

Cited by 1 publication

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Corticosteroids have both immunosuppressive and anti-inflammatory effects. Corticosteroids directly affect steroid hormone receptors and disrupt the immune response and the inflammation process at some levels ( Bodick et al, 2015 ; Frederick et al, 2021 ). In that way, corticosteroids diminish the permeability of blood vessels and can prevent inflammatory cells accumulation, neutrophil superoxide production, metalloprotease, and their activators, as well as inhibit the production of multiple inflammatory mediators like leukotrienes and prostaglandin.…”

Section: Intra-articular Drug Deliverymentioning

confidence: 99%

An update on the effect of intra-articular intervention strategies using nanomaterials in osteoarthritis: Possible clinical application

Amirsaadat

Amirazad²,

Hashemihesar³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common progressive condition affecting joints. It mainly affects the knees and hips as predominant weight-bearing joints. Knee osteoarthritis (KOA) accounts for a large proportion of osteoarthritis and presents numerous symptoms that impair quality of life, such as stiffness, pain, dysfunction, and even deformity. For more than two decades, intra-articular (IA) treatment options for managing knee osteoarthritis have included analgesics, hyaluronic acid (HA), corticosteroids, and some unproven alternative therapies. Before effective disease-modifying treatments for knee osteoarthritis, treatments are primarily symptomatic, mainly including intra-articular corticosteroids and hyaluronic acid, so these agents represent the most frequently used class of drugs for managing knee osteoarthritis. But research suggests other factors, such as the placebo effect, have an essential role in the effectiveness of these drugs. Several novel intra-articular therapies are currently in the clinical trial processes, such as biological therapies, gene and cell therapies. Besides, it has been shown that the development of novel drug nanocarriers and delivery systems could improve the effectiveness of therapeutic agents in osteoarthritis. This review discusses the various treatment methods and delivery systems for knee osteoarthritis and the new agents that have been introduced or are in development.

show abstract

Section: Intra-articular Drug Deliverymentioning

confidence: 99%