2021
DOI: 10.21203/rs.3.rs-222281/v1
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RNA-seq analysis of circRNA profiles in the lens of Crybb2 knockout mice

Abstract: Background: Currently, there is little information on the expression profiles of circRNAs in the lens. βB2-crystallin (CRYBB2) is an abundant protein in the mammalian lens, and its abnormal expression contributes to the development of cataract. This study aimed at exploring how Crybb2 knockout could modulate the expression profiles of circRNAs in mouse lens. Methods and Results: We extracted total RNAs from the lens of wide-type (WT) and Crybb2 -/- mice and after depleted their rRNAs and broken the remaining R… Show more

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