RNA-seq analysis of phagocytic cells from murine epididymal white adipose tissue shows immunosenescence and age-related phosphorus metabolism

Nwadiugwu, Martin C

doi:10.1007/s13577-021-00663-4

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…The accumulation of deficits and distinct changes in gene expression and tissue regulation have been reported in several aging-related studies [ 11 , 21 , 22 , 44 ]. Deficits such as the accumulation of DSBs in neurons disrupt neuroimmune communication and cause late-stage DNA damage [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Molecular Mechanisms of Alzheimer’s Disease from Genetic Studies

Nwadiugwu

Shen

Deng

2023

Biology

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The devastating effects of Alzheimer’s disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to identify common causes of molecular imbalance in AD and their potential mechanisms for continuing research. A narrative synthesis of molecular mechanisms in AD from primary studies that employed single-cell sequencing (scRNA-seq) or spatial genomics was conducted using Embase and PubMed databases. We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. What changed from previous findings in contrast to results obtained were explored to find potential factors for AD-modifying investigations.

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