RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression

Williams, Randy P.; Lesseur, Corina; Cheng, Haoxiang; Li, Qian; Deyssenroth, Maya; Molteno, Christopher D.; Meintjes, Ernesta M.; Jacobson, Sandra W.; Jacobson, Joseph L.; Wainwright, Helen; Hao, Ke; Chen, Jia; Carter, R. Colin

doi:10.1016/j.gene.2023.147951

Gene

2024

DOI: 10.1016/j.gene.2023.147951

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RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression

Randy P. Williams,

Corina Lesseur,

Haoxiang Cheng

et al.

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Prenatal alcohol exposure is associated with changes in placental gene co-expression networks

Deyssenroth,

Williams,

Lesseur

et al. 2024

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Alcohol consumption during pregnancy can result in a range of adverse postnatal outcomes among exposed children. However, identifying at-risk children is challenging given the difficulty to confirm prenatal alcohol exposure and the lack of early diagnostic tools. Placental surveys present an important opportunity to uncover early biomarkers to identify those at risk. Here, we report the first transcriptome-wide evaluation to comprehensively evaluate human placental pathways altered by fetal alcohol exposure. In a prospective longitudinal birth cohort in Cape Town, South Africa, we performed bulk tissue RNAseq in placenta samples from 32 women reporting heavy drinking during pregnancy and 30 abstainers/light drinkers. Weighted gene co-expression network analysis (WGCNA) and differential gene expression analysis were performed to assess associations between fetal alcohol exposure and placental gene expression patterns at a network-wide and single gene level, respectively. The results revealed altered expression in genes related to erythropoiesis and angiogenesis, which are implicated in established postnatal phenotypes related to alcohol exposure, including disruptions in iron homeostasis, growth, and neurodevelopment. The reported findings provide insights into the molecular pathways affected by prenatal alcohol exposure and highlight the potential of placental biomarkers for detecting and understanding the effects of alcohol on fetal development.

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Prenatal alcohol exposure is associated with changes in placental gene co-expression networks

Deyssenroth,

Williams,

Lesseur

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

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RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression

Cited by 1 publication

References 78 publications

Prenatal alcohol exposure is associated with changes in placental gene co-expression networks

Prenatal alcohol exposure is associated with changes in placental gene co-expression networks

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