2019
DOI: 10.1038/s41598-019-46886-2
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RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms

Abstract: Intracranial aneurysm (IA) is a socially important disease as a major cause of subarachnoid hemorrhage. Recent experimental studies mainly using animal models have revealed a crucial role of macrophage-mediated chronic inflammatory responses in its pathogenesis. However, as findings from comprehensive analysis of unruptured human IAs are limited, factors regulating progression and rupture of IAs in humans remain unclear. Using surgically dissected human unruptured IA lesions and control arterial walls, gene ex… Show more

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Cited by 23 publications
(18 citation statements)
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“…1 E). Because some of these factors play a role in the pathogenesis of IAs 8 10 , the contribution of neutrophils to the pathogenesis of IAs in terms of inflammation is further supported.
Figure 1 Comprehensive gene expression profile analysis of rupture-prone IAs and the remaining circle of Willis.
…”
Section: Resultsmentioning
confidence: 99%
“…1 E). Because some of these factors play a role in the pathogenesis of IAs 8 10 , the contribution of neutrophils to the pathogenesis of IAs in terms of inflammation is further supported.
Figure 1 Comprehensive gene expression profile analysis of rupture-prone IAs and the remaining circle of Willis.
…”
Section: Resultsmentioning
confidence: 99%
“…We picked up GPR120 (free fatty acid receptor 4 (FFAR4)) as a putative therapeutic target from GPCRs whose expression was significantly upregulated in human unruptured IA lesions (n = 4) compared with those in control arterial walls (n = 3) (p = 7.95E −10 ) from previously obtained comprehensive gene expression profile data by RNA-sequencing analysis [10] (ID number #PRJNA553307 at BioProject database (http://www. ncbi.nlm.nih.gov/bioproject)).…”
Section: Resultsmentioning
confidence: 99%
“…The pharmacological measures interfering NF-κB pathway may thus become a reasonable strategy as the treatment of IAs. To explore a therapeutic target, we selected G-protein coupled receptors (GPCRs), that were upregulated in IA walls compared with those in the control arterial walls, as candidates [10] because GPCRs are on the top of signal transduction cascades and, thereby, inhibition of these receptors is presumably efficient and effective. We, in the present study, have then verified the potential of one of such upregulated GPCRs in lesions, GPR120, as a therapeutic target because GPR120, a receptor of ω3 fatty acids, could inhibit NF-κB activation [11].…”
Section: Introductionmentioning
confidence: 99%
“…1e). Because some of these factors play a role in the pathogenesis of IAs [8][9][10], the contribution of neutrophils to the pathogenesis of IAs in terms of inflammation is further supported.…”
Section: Discussionmentioning
confidence: 99%