RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer

Hashim, Adnan; Rizzo, Francesca; Marchese, Giovanna; Ravo, Maria; Tarallo, Roberta; Nassa, Giovanni; Giurato, Giorgio; Santamaria, Gianluca; Cordella, Angela; Cantarella, Concita; Weisz, Alessandro

doi:10.18632/oncotarget.2476

Cited by 153 publications

(158 citation statements)

References 30 publications

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“…PIWI family proteins have been shown to be aberrantly expressed and associated with poor prognosis in ovarian, colorectal, gastric, hepatocellular, esophageal, and pancreatic cancers (13)(14)(15)(16)(17)(18), and piRNA expression has been observed in bladder, colon, lung, cervical, breast, hepatocellular, and gastric cancers (19)(20)(21)(22)(23)(24). Our recent study also identified a genetic variant in a mature piRNA sequence that is associated with breast cancer risk (25).…”

Section: Introductionmentioning

confidence: 69%

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Jacobs

Qin

Lerro

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: PIWI-interacting RNAs (piRNAs), the largest class of noncoding RNAs in mammals, cooperate with PIWI proteins to safeguard the genome from insertional mutations during germline development. Although a growing number of studies have linked the PIWI-piRNA pathway to carcinogenesis, the role of piRNAs in glioma has not been explored.Methods: Utilizing directly measured and imputed genotypes from the GliomaScan genome-wide association study (1,840 cases and 2,401 controls), genetic variants in 1,428 piRNAs were analyzed for association with glioma risk. In vitro assays were performed to interrogate the functional impact of a top identified piRNA and its variant allele.Results: Variants in five piRNAs were considered to be associations of interest and four of these showed narrow clusters of enhanced association signals surrounding the index variant. Functional analyses of one of these piRNAs, piR-598, revealed that transfection of the wild-type piRNA impacted expression of

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Section: Introductionmentioning

confidence: 69%

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Jacobs

Qin

Lerro

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In breast cancer, PIWIL2 and PIWIL4, not PIWIL1 and PIWIL3, had high expression levels in clinical patients [60]. In gastric cancer, the expression of PIWIL1-4 was significantly correlated with the T-stage, lymph node metastasis and clinical TNM (cTNM), and elevated PIWIL1 and PIWIL2 expressions were associated with poorer overall survival, and PIWIL1 expression was suggested to be an independent prognostic factor [39].…”

Section: Piwis May Be Biomarkers For Cancer Diagnosis and Prognosismentioning

confidence: 99%

Emerging roles for PIWI proteins in cancer

Tan¹,

Liu²,

Liao³

et al. 2015

ABBS

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It is generally accepted that PIWI proteins are predominately expressed in the germline but absent in somatic tissues. Their best-characterized role is to suppress transposon expression, which ensures genomic stability in the germline. However, increasing evidence has suggested that PIWI proteins are linked to the hallmarks of cancer defined by Weinberg and Hanahan, such as cell proliferation, anti-apoptosis, genomic instability, invasion and metastasis. This provides new possibilities for anticancer therapies through the targeting of PIWI proteins, which may have fewer side effects due to their potential classification as a CTA (cancer/testis antigen). Furthermore, PIWI has been proposed to act as a diagnostic and prognostic marker for many types of cancer, and even to differentiate early-and late-stage cancers. We herein summarize the latest progress in this exciting field, hoping to encourage new investigations of PIWIs in cancer biology that will help to develop new therapeutics for clinical application.

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“…Through deepsequencing analysis of the breast cancer transcriptome, Hashim et al identified numerous piRNAs that are differentially expressed in breast cancer cell lines and tumor biopsies when compared with normal counterparts. The potential mRNA targets for cancer-specific piRNAs were also analyzed [170]. Through genotypic screening of a panel of single-nucleotide polymorphism (SNP)-containing piRNAs, Fu et al [171] identified the breast cancer-specific variant of piR-021285 with SNP rs1326306 .…”

Section: Cd24mentioning

confidence: 99%

Noncoding RNAs in breast cancer

Lo¹,

Wolfson²,

Zhou³

et al. 2015

Briefings in Functional Genomics

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The mammalian transcriptome has recently been revealed to encompass a large number of noncoding RNAs (ncRNAs) that play a variety of important regulatory roles in gene expression and other biological processes. MicroRNAs (miRNAs), the best studied of the short noncoding RNAs (sncRNAs), have been extensively characterized with regard to their biogenesis, function and importance in tumorigenesis. Another class of sncRNAs called piwi-interacting RNAs (piRNAs) has also gained attention recently in cancer research owing to their critical role in stem cell regulation. Long noncoding RNAs (lncRNAs) of >200 nucleotides in length have recently emerged as key regulators of developmental processes, including mammary gland development. lncRNA dysregulation has also been implicated in the development of various cancers, including breast cancer. In this review, we describe and discuss the roles of sncRNAs (including miRNAs and piRNAs) and lncRNAs in the initiation and progression of breast tumorigenesis, with a focus on outlining the molecular mechanisms of oncogenic and tumor-suppressor ncRNAs. Moreover, the current and potential future applications of ncRNAs to clinical breast cancer research are also discussed, with an emphasis on ncRNA-based diagnosis, prognosis and future therapeutics.

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RNA sequencing identifies specific PIWI-interacting small non-coding RNA expression patterns in breast cancer

Cited by 153 publications

References 30 publications

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Emerging roles for PIWI proteins in cancer

Noncoding RNAs in breast cancer

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