RNA stabilized blood tubes to measure haemoglobin concentration

Leuenberger, Nicolas; Schobinger, Céline; Salamin, Olivier; Saugy, Martial; Kuuranne, Tiia

doi:10.1002/dta.2179

Cited by 1 publication

(1 citation statement)

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“…Taking into account the time period between sample collection and analysis (CAT) and the storage temperature (T) of the sample, the BSS was defined by BSS = CAT + 3xT, and values below 85 were found to guarantee the stability of parameters relevant for ABP analyses. Alternatively, blood collection tubes designed for RNA analyses were shown to allow for [Hb] determinations comparable to conventional EDTA‐containing sampling devices . RNA‐stabilized specimens allowed for reproducible [Hb] analyses also when stored/shipped at room temperature over a period of 5 days, which was considered a significant advantage over commonly employed plasma samples necessitating controlled cooled conditions.…”

Section: Manipulation Of Blood and Blood Componentsmentioning

confidence: 99%

Annual banned‐substance review: Analytical approaches in human sports drug testing

Thevis

Kuuranne

Geyer

2017

Drug Testing and Analysis

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Several high-profile revelations concerning anti-doping rule violations over the past 12 months have outlined the importance of tackling prevailing challenges and reducing the limitations of the current anti-doping system. At this time, the necessity to enhance, expand, and improve analytical test methods in response to the substances outlined in the World Anti-Doping Agency's (WADA) Prohibited List represents an increasingly crucial task for modern sports drug-testing programs. The ability to improve analytical testing methods often relies on the expedient application of novel information regarding superior target analytes for sports drug-testing assays, drug elimination profiles, alternative test matrices, together with recent advances in instrumental developments. This annual banned-substance review evaluates literature published between October 2016 and September 2017 offering an in-depth evaluation of developments in these arenas and their potential application to substances reported in WADA's 2017 Prohibited List.

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Section: Manipulation Of Blood and Blood Componentsmentioning

confidence: 99%