RNA Synthesis in Pons Necessary for Maintenance of Bladder Overactivity After Cerebral Infarction in Rat.

Abstract

These results indicate that an RNA synthesis inhibitor can prevent a late stage of bladder overactivity. Transcription in the dorsal pontine tegmentum was found to be necessary to maintain the long lasting bladder overactivity caused by cerebral infarction.

Sphincter EMG for Diagnosing Multiple System Atrophy and Related Disorders

“…In lesions above the brainstem, detrusor overactivity is considered an exaggerated micturition reflex 66 . This is in line with the fact that detrusor overactivity appearing after experimental stroke requires mRNA synthesis in the PMC 83 . The exaggeration of the micturition reflex might be brought about not only by decreased inhibition of the brain (by central cholinergic and D1 dopaminergic mechanisms); that is, it might be further facilitated by glutamatergic and D2 dopaminergic mechanisms 82 .…”

Mechanism of bladder dysfunction in idiopathic normal pressure hydrocephalus

“…DO appearing after experimental stroke requires mRNA synthesis in the PMC, based on the finding that it could be antagonized by microinjection of actinomycin D, an RNA synthesis inhibitor, in the PMC. 27 Although NPH is a diffuse brain disease with dilated ventricles, patients with iNPH reveal frontal lobe hypoperfusion 28 and decreased dopaminergic D2 receptor density, 29 which can be the anatomical substrate for the development of DO in this disorder. In particular, DO is usually the sole autonomic abnormality in brain diseases; for example, DO is not necessarily accompanied by postural hypotension that has been reported to occur at or below the medullar circulation center.…”

Sphincter EMG as a diagnostic tool in autonomic disorders

“…In lesions above the brainstem, detrusor overactivity is considered an exaggerated micturition reflex [65]. This is in line with the fact that detrusor overactivity appearing after experimental stroke requires mRNA synthesis in the PMC [82]. The exaggeration of the micturition reflex might be brought about not only by decreased inhibition of the brain (by central cholinergic and D1 dopaminergic mecha- 1 Neural circuitry relevant to micturition.…”