RNA takes over control of DNA break repair

Storici, Francesca; Tichon, Ailone

doi:10.1038/ncb3645

Cited by 14 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aberrantly enhanced DNA damage repair leads to therapeutic resistance in many types of cancer [ 1 , 2 ]. Recently, long non-coding RNAs (lncRNAs) have been shown as indispensable participants in DNA damage repair and provide novel targets for overcoming cancer resistance [ 3 , 4 ]. However, the exact roles of most lncRNAs in DNA damage repair remain largely unknown.…”

Section: Main Textmentioning

confidence: 99%

Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance

Liu

Chen²,

Huang³

et al. 2021

Mol Cancer

View full text Add to dashboard Cite

Section: Main Textmentioning

confidence: 99%

Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance

Liu

Chen²,

Huang³

et al. 2021

Mol Cancer

View full text Add to dashboard Cite

“…The cell cycle phase determines the triggering of one or the other, but in both cases, they require the intervention of other DDR proteins (54). In addition to the proteins involved in DDR, many ncRNAs are essential to the damage response mechanisms (60)(61)(62). Furthermore, these ncRNAs modulate the DDR elements' activity after irradiation, promoting radioresistant or radiosensitive phenotypes (9).…”

Section: Ncrnas Involved In Dna Damagementioning

confidence: 99%

Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer

et al. 2021

View full text Add to dashboard Cite

The resistance that Triple-Negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, develops against radiotherapy is a complex phenomenon involving several regulators of cell metabolism and gene expression; understanding it is the only way to overcome it. We focused this review on the contribution of the two leading classes of regulatory non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), against ionizing radiation-based therapies. We found that these regulatory RNAs are mainly associated with DNA damage response, cell death, and cell cycle regulation, although they regulate other processes like cell signaling and metabolism. Several regulatory RNAs regulate multiple pathways simultaneously, such as miR-139-5p, the miR-15 family, and the lncRNA HOTAIR. On the other hand, proteins such as CHK1 and WEE1 are targeted by several regulatory RNAs simultaneously. Interestingly, the study of miRNA/lncRNA/mRNA regulation axes increases, opening new avenues for understanding radioresistance. Many of the miRNAs and lncRNAs that we reviewed here can be used as molecular markers or targeted by upcoming therapeutic options, undoubtedly contributing to a better prognosis for TNBC patients.

show abstract

“…Prompted by the discovery of DDRNAs (see section for details), the group of d’Adda di Fagagna (IFOM, Italy) in collaboration with the group of Nils Walter (University of Michigan, USA) has more recently probed the transcriptional landscape around a DSB in search of DDRNA precursors. By single-molecule fluorescent in situ hybridization (smFISH, see section for details) and reverse transcription followed by quantitative PCR (RT-qPCR) techniques, a novel class of lncRNAs named damage-induced lncRNAs (dilncRNAs) transcribed by RNAP II upon damage from and toward the DNA ends was uncovered. , Induction of de novo transcription from DSBs was demonstrated in various mammalian cellular systems. For these experiments, multiple endonucleases were used to generate DSBs at exogenous integrated constructs as well as endogenous genomic loci, in both transcribed and nontranscribed regions.…”

Section: Crosstalk Between Ncrna Rnai and The Cellular Response To Dn...mentioning

confidence: 99%

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

et al. 2018

Self Cite

View full text Add to dashboard Cite

Coding for proteins has been considered the main function of RNA since the "central dogma" of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA, ranging from the support of polypeptide synthesis, to the assembly of subnuclear structures, to gene expression modulation. Cellular RNA has therefore been recognized as a central player in often unanticipated biological processes, including genomic stability. This ever-expanding list of functions inspired us to think of RNA as a "smart" phone, which has replaced the older obsolete "cellular" phone. In this review, we summarize the last two decades of advances in research on the interface between RNA biology and genome stability. We start with an account of the emergence of noncoding RNA, and then we discuss the involvement of RNA in DNA damage signaling and repair, telomere maintenance, and genomic rearrangements. We continue with the depiction of single-molecule RNA detection techniques, and we conclude by illustrating the possibilities of RNA modulation in hopes of creating or improving new therapies. The widespread biological functions of RNA have made this molecule a reoccurring theme in basic and translational research, warranting it the transcendence from classically studied "cellular" RNA to "smart" RNA.

show abstract

RNA takes over control of DNA break repair

Cited by 14 publications

References 14 publications

Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance

Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance

Non-Coding RNAs Associated With Radioresistance in Triple-Negative Breast Cancer

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

Contact Info

Product

Resources

About