RNAi Suppressors: Biology and Mechanisms

Sanan‐Mishra, Neeti; Chakraborty, Supriya; Gupta, Dinesh; Mukherjee, Sunil Kumar

doi:10.1007/978-3-319-55520-1_11

Cited by 13 publications

(7 citation statements)

References 156 publications

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“…Depending on the nature of viral suppressors, they are capable of inhibiting RNA-silencing reactions at every stage of RNA silencing. Such defense and counterdefense have been reviewed in several occasions ( Agrawal et al, 2003 ; Csorba et al, 2015 ; Sanan-Mishra et al, 2017 ), and here, we will focus on few facts associated with secondary VsiRNAs.…”

Section: Viruses and Secondary Sirnasmentioning

confidence: 99%

Secondary siRNAs in Plants: Biosynthesis, Various Functions, and Applications in Virology

et al. 2021

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The major components of RNA silencing include both transitive and systemic small RNAs, which are technically called secondary sRNAs. Double-stranded RNAs trigger systemic silencing pathways to negatively regulate gene expression. The secondary siRNAs generated as a result of transitive silencing also play a substantial role in gene silencing especially in antiviral defense. In this review, we first describe the discovery and pathways of transitivity with emphasis on RNA-dependent RNA polymerases followed by description on the short range and systemic spread of silencing. We also provide an in-depth view on the various size classes of secondary siRNAs and their different roles in RNA silencing including their categorization based on their biogenesis. The other regulatory roles of secondary siRNAs in transgene silencing, virus-induced gene silencing, transitivity, and trans-species transfer have also been detailed. The possible implications and applications of systemic silencing and the different gene silencing tools developed are also described. The details on mobility and roles of secondary siRNAs derived from viral genome in plant defense against the respective viruses are presented. This entails the description of other compatible plant–virus interactions and the corresponding small RNAs that determine recovery from disease symptoms, exclusion of viruses from shoot meristems, and natural resistance. The last section presents an overview on the usefulness of RNA silencing for management of viral infections in crop plants.

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Section: Viruses and Secondary Sirnasmentioning

confidence: 99%

Secondary siRNAs in Plants: Biosynthesis, Various Functions, and Applications in Virology

et al. 2021

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“…Other biomolecules that are promising as drug antivirals are interference RNAs (iRNAs). These macromolecules are small non-coding RNAs associated with controlling the expression of genetic information ( Wilson and Doudna, 2013 ) and have been described as promising candidates for the treatment of hepatitis B virus (HBV), HCV, HIV, and human T-cell lymphotropic virus (HTLV) infections ( Ma et al, 2007 ; Shah and Schaffer, 2011 ; Sanan-Mishra et al, 2017 ). Short interference RNAs (siRNAs) were described as being effective for in vitro antiviral treatment of FIPV, a type of FCoV ( McDonagh et al, 2011 , 2015 ).…”

Section: Inhibitors Of the Cov Replicative Cyclementioning

confidence: 99%

Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?

et al. 2020

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Coronaviruses (CoVs) are a group of viruses from the family Coronaviridae that can infect humans and animals, causing mild to severe diseases. The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global threat, urging the development of new therapeutic strategies. Here we present a selection of relevant compounds that have been described from 2005 until now as having in vitro and/or in vivo antiviral activities against human and/or animal CoVs. We also present compounds that have reached clinical trials as well as further discussing the potentiality of other molecules for application in (re)emergent CoVs outbreaks. Finally, through rationalization of the data presented herein, we wish to encourage further research encompassing these compounds as potential SARS-CoV-2 drug candidates.

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“…The interference RNA (iRNAs) are small noncoding RNAs associated with controlling the expression of genetic information (Wilson and Doudna, 2013), and has been described as promising candidate for the treatment of innumerous diseases, as virus infection (Y et al, 2007;Shah and Schaffer, 2011;Sanan-Mishra et al, 2017). The short interference RNAs (siRNAs) were described as an effective antiviral treatment for the Feline infectious peritonitis virus (FIPV), a type of Feline coronavirus (FCoV) in vitro (McDonagh et al, 2011(McDonagh et al, , 2015.…”

Section: Different Approaches For Covs Treatmentmentioning

confidence: 99%

Antivirals against human and animal Coronaviruses: different approach in SARS-CoV-2 treatment

Santos¹,

Grosche²,

Sabino-Silva³

et al. 2020

Preprint

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Coronaviruses (CoVs) is a group of viruses from Coronaviridae family which are able to infect human and animals, causing mild to severe disease. The recently emergence of SARS-CoV-2, worldwide classified as a pandemic disease represent a threat to global public health. Associated with the high transmissibility, the lack of vaccine and antivirals drugs demonstrates the need to develop novel therapies to treat infected patients. This review aims to summarize compounds from 2005 up to now with already described antiviral activity in vitro and in vivo to human and animal CoVs. These compounds may present as a source of molecules with potent biological activities which could be further investigated for their use as novel approaches against SARS-CoV-2.

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RNAi Suppressors: Biology and Mechanisms

Cited by 13 publications

References 156 publications

Secondary siRNAs in Plants: Biosynthesis, Various Functions, and Applications in Virology

Secondary siRNAs in Plants: Biosynthesis, Various Functions, and Applications in Virology

Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?

Antivirals against human and animal Coronaviruses: different approach in SARS-CoV-2 treatment

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