RNase Levels in golden hamsters with dhpn induced pancreatic cancer

Abstract

Twenty Syrian golden hamsters recieved weekly injections of pancreatic cancer inducing DHPN. Their Poly (U) specific serum RNase levels were significantly elevated when compared to the control levels. Following salt fractionation, Poly (U) specific activity was present in both the 40% and 50% salt saturated fractions. Tissue assays showed that Poly (U) specific RNase was present in both pancreas and liver tissue extract, although the liver tissue RNase had a different pH maximum than that of the serum RNase.

Biology of Circulating Nucleic Acids and Possible Roles in Diagnosis and Treatment in Diabetes and Cancer

“…Thus, although there was a real increase in the cancer patient RNAase levels, the average values for normal individuals were also relatively high [46]. Similar results were reported for Syrian golden hamsters that had been induced to develop pancreatic cancer [47]. In consequence, if released RNA is not always broken down, it must be protected in some way from the RNAase probably by being released in either apoptotic vesicles [48] or exosomes [49] or virtosomes [50].…”

“…They have been shown to be released from bacteria [86][87][88][89], human [47][48][49] other mammalian [86][87][88][89][90][91][92][93][94][95], avian [96], amphibian [97][98][99][100] and plant cells [101]. The virtosomes appear to function as intercellular messengers that have been demonstrated to influence DNA synthesis [95] and the immune response [102,103].…”