2024
DOI: 10.3389/fimmu.2023.1324516
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RNF5: inhibiting antiviral immunity and shaping virus life cycle

Junyi Ge,
Leiliang Zhang

Abstract: RNF5 is an E3 ubiquitin ligase involved in various physiological processes such as protein localization and cancer progression. Recent studies have shown that RNF5 significantly inhibits antiviral innate immunity by promoting the ubiquitination and degradation of STING and MAVS, which are essential adaptor proteins, as well as their downstream signal IRF3. The abundance of RNF5 is delicately regulated by both host factors and viruses. Host factors have been found to restrict RNF5-mediated ubiquitination, maint… Show more

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