To study the side slip and rollover threshold of large bus in slope–curve section under adverse weather, factors that affect the safety of large buses that run in slope–curve section, such as rain, snow, cross-wind environmental factors, and road geometry, were analyzed to obtain the friction coefficient of the road surface under different rainfall and snowfall intensities through field measurements and to determine the six-component force coefficient of wind that acts on large buses through wind tunnel tests. The force analysis of large bus in slope-curve section was carried out, and the mechanical equations of large bus under the limit conditions of sideslip and rollover in slope-curve section were established. TruckSim simulation test platform was used to establish a three-dimensional road model and large bus mechanical model at a design speed of 100 km/h. Input parameters, such as cross-wind speed and road friction coefficient, simulate the impact of wind-rain/snow coupling. Under the combined action of wind-rain/snow, the operation test of large bus in slope-curve section was carried out, and the key parameters and indicators of the sideslip and rollover of large bus in slope-curve section were outputted and analyzed. The sudden change point of lateral acceleration is the judging condition for sideslip of large bus in slope-curve section under different road friction coefficient (0.2–0.7), changing from 0.15m/s2 and stabilizing to 0.52 m/s2, and a 0N vertical reaction force of the inner tire is the critical judging condition for rollover under road friction coefficient0.8, and the operating speed thresholds were proposed under different road friction coefficient. This study is expected to provide theoretical support for the speed limit of large bus in slope-curve section under adverse weather.