Purpose: Czech motorways and national roads form the primary road network, which is critical in terms of safety. To be able to rationally manage network safety in both planning and operation stages, quality network-wide data and tools are needed. While such tools already exist in some countries, their transferability is limited. Authors therefore collected data and used it to develop tools, which allowed conducting state-of-the-art road safety impact assessment and network safety ranking in the Czech conditions. In addition to primary road network, focus was widened to include also secondary roads, in order to enable assessment of impacts on adjacent road network. Methods: Accident, road and traffic data was collected, using not only existing databases, but also including own collection of traffic volumes on motorway interchanges. Data was used to develop the tools, based on accident prediction models and accident modification factors. Results: The final accident prediction models and accident modification factors enabled conducting road safety impact assessment, for which simple on-line tool was also developed. For network safety ranking, accident prediction models were applied according to the Empirical Bayes method, in order to determine potential for safety improvement of the studied road network elements, with the final priority list visualized in an on-line map. Both outputs are shortly presented in the paper. Conclusions: Data and sample size limitations lead to some compromises in modelling, such as using fixed proportions of observed accident severities or omitted variables. Nevertheless, the study established the practical framework for both road safety impact assessment and network safety ranking. It may serve as an example for other member countries, which also lack their local tools. Follow-up studies may focus on future model updating and improvements, as well as development of local accident modification factors.